Virchows Archiv B

, 26:215 | Cite as

Cell Kinetics of mouse urinary bladder epithelium

III. A histologic and ultrastructural study of bladder epithelium during regeneration after a single dose of cyclophosphamide, with special reference to the mechanism by which polyploid cells are formed
  • Tore Farsund
  • Erik Dahl


In order to see whether the polyploid cells lining the mouse urinary bladder are formed by nuclear fusion, such epithelium was studied under the light and electron microscope forthy-eight hours after an injection of cyclophosphamide when the bladder epithelium regenerates with rapid formation of many diploid, tetraploid and octoploid cells. The probability of seing fusion, if it occurs, ought then to be high. Serial sections of many specimens from four mice revealed no signs of fusion. Thus we found no support for the theory that polyploid cells are formed by nuclear fusion.

Key words

Cyclophosphamide Fusion Polyploidy Regeneration Repeated cycling Urothelium 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Tore Farsund
    • 1
    • 2
  • Erik Dahl
    • 1
    • 2
  1. 1.Institute of PathologyUniversity of OsloRikshospitalet
  2. 2.Department of Anatomy, Dental FacultyUniversity of OsloNorway

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