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Virchows Archiv B

, 25:1 | Cite as

The proliferation of chondrocytes and pannus in adjuvant arthritis

  • W. Mohr
  • A. Wild
Article
  • 9 Downloads

Summary

Cell proliferation in the pannus formation of adjuvant arthritis was studied by autoradiography. It was found that after day 9 an increased cell proliferation starts in the joint capsule recessus and synovial villi on the injected side. From these proliferating cells a pannus, which during the first phase frequently consists only of few cell layers, extends over the cartilage surface. With advancing disease the thickness of the pannus increases and further centripetal growth may cause the entire cartilage surface to be covered. This proliferating pannus tissue may invade the cartilage and destroy it. Since in this area of destruction labelled cells are frequently present, it may be assumed that proliferating cells with a high enzyme content are particularly responsible for the immediate degradation of cartilage. No involvement of chondrocytes in pannus formation was confirmed by the methods employed. There was neither increased proliferation of surface chondrocytes nor increased proliferation of chondrocytes in the depth of cartilage.

Keywords

Adjuvant arthritis Pannus formation Cell proliferation 

Zusammenfassung

Autoradiographisch wurde die Zellproliferation bei der Pannusentwicklung der Adjuvansarthritis der Ratte untersucht. Auf der injizierten Seite beginnt am 9. Tage nach der Adjuvansinjektion eine verstärkte Zellproliferation in den Recessus und Zotten des Gelenkkapselgewebes. Von diesem proliferierenden Gewebe erstreckt sich in der initialen Phase der Erkrankung ein wenige Zellagen breiter Pannus über die Knorpelfläche. Mit der Fortdauer der Erkrankung nimmt das Pannusgewebe an Dicke zu und kann die gesamte Knorpeloberfläche bedecken und den hyalinen Gelenkknorpel invadieren und zerstören. Da in der unmittelbaren Destruktionsfront häufig eine große Anzahl proliferierender Pannuszellen vorhanden ist, wird geschlossen, daß solche enzymreichen Zellen für den Knorpelabbau verantwortlich zu machen sind. Eine Beteiligung der Chondrozyten an der Pannusbildung konnte mit der angewandten Methode nicht nachgewiesen werden. Es konnte weder eine verstärkte Proliferation der oberflächlichen Chondrozyten noch der Chondrozyten in tiefen Knorpelbereichen gefunden werden.

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • W. Mohr
    • 1
  • A. Wild
    • 1
  1. 1.Abteilung Pathologie der Universität Ulm und Fachbereich Rheumaforschung der E. MerckDarmstadt

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