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Virchows Archiv B

, Volume 11, Issue 1, pp 66–79 | Cite as

Non-G cell gastrin-producing tumours of the pancreas

  • G. Vassallo
  • E. Solcia
  • G. Bussolati
  • Julia M. Polak
  • A. G. E. Pearse
Article
  • 11 Downloads

Summary

Three pancreatic gastrinomas, associated with the Zollinger-Ellison syndrome, were examined by staining, cytochemical and immunohistochemical, and ultrastructural techniques in order to compare the properties of their storage granules with those of normal gastrin-producing cells. In all three cases, despite their positive anti-gastrin fluorescence, there was only a partial correspondence of properties with those of the pyloric G cell or the pancreatic islet D cell.

It is concluded that the available evidence supports the origin of pancreatic gastrinomas from the gastrin-secreting D cell of the normal islet. The relationship of the “small cell” of the normal islet to the D cell on the one hand, and to the gastrinoma cell on the other, has not been determined.

Keywords

Cell Granule Islet Cell Pancreatic Islet Endocrine Cell Islet Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • G. Vassallo
    • 1
    • 2
  • E. Solcia
    • 1
    • 2
  • G. Bussolati
    • 1
    • 2
  • Julia M. Polak
    • 1
    • 2
  • A. G. E. Pearse
    • 2
  1. 1.Institute of Pathological AnatomyUniversity of PaviaPaviaItaly
  2. 2.Department of HistochemistryRoyal Postgraduate Medical SchoolLondonEngland

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