Fine structural alterations in mesothelial cells associated with cardiac anomaly
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Three rare ultrastructural alterations were found in the pleural mesothelial cells from a 38-week gestation human baby. These were intranuclear fibrillary bundles, para-nuclear tubular aggregates and a proliferation of endoplasmic reticulum with multiple concentric terminals which contained linear, dot or bar-like intracisternal condensations. These structures are most likely exaggerated physiological or pathophysiological products of the cells and may represent altered processes of DNA transcription into RNA and RNA translation into the product. There is no direct proof that these changes are either etiological in, or sequential to, the congenital anomaly the baby has had.
KeywordsEndoplasmic Reticulum Mesothelial Cell Cardiac Anomaly Herpes Simplex Encephalitis Parallel Filament
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