Summary
Three rare ultrastructural alterations were found in the pleural mesothelial cells from a 38-week gestation human baby. These were intranuclear fibrillary bundles, para-nuclear tubular aggregates and a proliferation of endoplasmic reticulum with multiple concentric terminals which contained linear, dot or bar-like intracisternal condensations. These structures are most likely exaggerated physiological or pathophysiological products of the cells and may represent altered processes of DNA transcription into RNA and RNA translation into the product. There is no direct proof that these changes are either etiological in, or sequential to, the congenital anomaly the baby has had.
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References
Baringer, J. R.: Tubular aggregates in endoplasmic reticulum in herpes simplex encephalitis. New Engl. J. Med.285, 943–945 (1971)
Baringer, J. R., Swoveland, P.: Tubular aggregates in endoplasmic reticulum: Evidence against their viral nature. J. Ultrastruct. Res.41 270–276 (1972)
Boquist, L.: Intranuclear rods in pancreatic islet β-cells. J. Cell Biol.43, 377–381 (1969)
Chandra, S.: Undulating tubules associated with endoplasmic reticulum in pathologic tissues. Lab. Invest.18, 422–428 (1968)
Clattenburg, R. E., Singh, R. P., Montemurro, D. G.: Intranuclear filamentous inclusions in neurons of the rabbit hypothalamus. J. Ultrastruct. Res.39, 549–555 (1972)
Fawcett, D. W.: An atlas of fine structure. The cell, p. 159. Philadelphia, Pennsylvania: W. B. Saunders Publishing Company 1966
Kuhn, C.: Fine structure of bronchiolo-alveolar cell carcinoma. Cancer (Philad.)30, 1107–1118 (1972)
Lin, H. S., Chen, I. L.: Intercisternal parallel filaments in the endoplasmic reticulum in cells of the rat subcommissural organ. J. Ultrastruct. Res.37, 401–410 (1971)
Martino, C. de, Accini, L., Andres, G. A.: Tubular structures associated with the endoplasmic reticulum in glomerular capillaries of Rhesus monkeys and nephritic man. Z. Zellforsch.97, 502–511 (1969)
Patrizi, G., Middelkamp, J. N.: Intranuclear structures in paracrystalline array. J. Ultrastruct. Res.27, 1–6 (1969)
Popoff, N., Stewart, S.: The fine structure of nuclear inclusions in the brain of experimental golden hamsters. J. Ultrastruct. Res.23, 347–361 (1968)
Seite, R.: Etude ultrastructural de divers types d’inclusions nucléaires dans les neurones sympathique du chat. J. Ultrastruct. Res.30, 152–165 (1970)
Stefani, S. S., Tonaki, H.: Fibrillar bundles in the nucleus of blood lymphocytes from leukemic and nonleukemic patients. Blood35, 243–249 (1970)
Uzman, B. G., Aito, H., Kasac, M.: Tubular arrays in the endoplasmic reticulum in human tumor cells. Lab. Invest.24, 492–498 (1971)
Valeri, V., Goncalves, R.P., Cruz, A.R., Laicine, E.: Tubular structure within the granular endoplasmic reticulum of the pars intermedia of toad hypophysis. J. Ultrastruct. Res.35, 197–200 (1971)
Wang, N. S.: Electron microscopy in the diagnosis of pleural mesotheliomas. Cancer (Philad.)31 1046–1054 (1973)
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This work was supported by a grant from the American Lung Association.
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Wang, NS. Fine structural alterations in mesothelial cells associated with cardiac anomaly. Virchows Arch. Abt. B Zellpath. 15, 217–222 (1974). https://doi.org/10.1007/BF02889338
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DOI: https://doi.org/10.1007/BF02889338