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Fine structure and silver-staining patterns of lysosome-like bodies in absorptive cells of the small intestine in normal children and children with a lysosomal storage disease

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Virchows Archiv B

Summary

The absorptive cells of the small intestine in normal children and children with a lysosomal storage disease were investigated with special attention to the fine structure and silver-staining pattern of lysosome-like bodies and related cell organelles.

In children with a lysosomal storage disease the absorptive cells contain enlarged lysosomelike bodies. The average diameter of these dense bodies is significantly larger than that of the dense bodies in normal children, whereas the size of the multivesicular bodies is unchanged. The silver-staining pattern showed great similarity between the lysosome-like bodies, Golgi apparatus, apical vesicles and tubules, and cell coat.

A possible crinophagic role of the lysosome-like bodies in the transport or secretion of cell coat material is discussed.

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Authors and Affiliations

  1. Interdepartmental Group for the Study of Lysosomal Storage Diseases, University of Leiden, The Netherlands

    L. A. Ginsel, W. Th. Daems, J. J. Emeis, P. M. A. Vio & J. J. van Gemund

  2. Laboratory for Electron Microscopy, University of Leiden, The Netherlands

    L. A. Ginsel, W. Th. Daems & J. J. Emeis

  3. Department of Pediatrics, University Hospital, The Netherlands

    P. M. A. Vio & J. J. van Gemund

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  1. L. A. Ginsel
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  2. W. Th. Daems
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  3. J. J. Emeis
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  4. P. M. A. Vio
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  5. J. J. van Gemund
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Ginsel, L.A., Daems, W.T., Emeis, J.J. et al. Fine structure and silver-staining patterns of lysosome-like bodies in absorptive cells of the small intestine in normal children and children with a lysosomal storage disease. Virchows Arch. Abt. B Zellpath. 13, 119–144 (1973). https://doi.org/10.1007/BF02889303

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