Virchows Archiv B

, Volume 13, Issue 1, pp 119–144 | Cite as

Fine structure and silver-staining patterns of lysosome-like bodies in absorptive cells of the small intestine in normal children and children with a lysosomal storage disease

  • L. A. Ginsel
  • W. Th. Daems
  • J. J. Emeis
  • P. M. A. Vio
  • J. J. van Gemund


The absorptive cells of the small intestine in normal children and children with a lysosomal storage disease were investigated with special attention to the fine structure and silver-staining pattern of lysosome-like bodies and related cell organelles.

In children with a lysosomal storage disease the absorptive cells contain enlarged lysosomelike bodies. The average diameter of these dense bodies is significantly larger than that of the dense bodies in normal children, whereas the size of the multivesicular bodies is unchanged. The silver-staining pattern showed great similarity between the lysosome-like bodies, Golgi apparatus, apical vesicles and tubules, and cell coat.

A possible crinophagic role of the lysosome-like bodies in the transport or secretion of cell coat material is discussed.


Golgi Apparatus Intestinal Epithelial Cell Dense Body Multivesicular Body Lysosomal Storage Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • L. A. Ginsel
    • 1
    • 2
  • W. Th. Daems
    • 1
    • 2
  • J. J. Emeis
    • 1
    • 2
  • P. M. A. Vio
    • 1
    • 3
  • J. J. van Gemund
    • 1
    • 3
  1. 1.Interdepartmental Group for the Study of Lysosomal Storage DiseasesUniversity of LeidenThe Netherlands
  2. 2.Laboratory for Electron MicroscopyUniversity of LeidenThe Netherlands
  3. 3.Department of PediatricsUniversity HospitalThe Netherlands

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