Virchows Archiv B

, Volume 35, Issue 1, pp 93–108 | Cite as

Different modes of mesenteric infiltration displayed by two rat leukemias

A study by scanning and transmission electron microscopy and by microcinematography
  • Peter Sträuli
  • Gisela Haemmerli
  • Curdin Tschenett
  • Radivoj V. Krstić


Infiltration of the mesentery after intraperitoneal implantation of two transplantable rat leukemias, the undifferentiated L5222 and the myeloid BNML, was studied by means of scanning and transmission electron microscopy, and microcinematography. In animals implanted with L5222 cells, contraction of the mesenteric mesothelium is a conspicuous feature. It occurs within the first 24 h after implantation and influences decisively the course of infiltration. In contrast, the presence of BNML cells leads to mesothelial contraction only in the terminal stage and, therefore, exerts no direct effect on infiltration. In addition, the two leukemias differ with regard to their cellular motility. Whereas L5222 cells locomote within the mesentery, only stationary movements are recorded with BNML cells. Based on the different interactions with the mesothelium and cell motilities, two distinct modes of infiltrating the mesentery could be ascertained for the two rat leukemias.

Key words

L5222 rat leukemia BNML rat leukemia Mesentery Mesothelium Cell motility 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Peter Sträuli
    • 1
  • Gisela Haemmerli
    • 1
  • Curdin Tschenett
    • 1
  • Radivoj V. Krstić
    • 2
  1. 1.Division of Cancer Research, Institute of PathologyUniversity of ZürichZürichSwitzerland
  2. 2.Institut d’Histologie et d’EmbryologieUniversité de LausanneLausanneSwitzerland

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