Virchows Archiv B

, Volume 23, Issue 1, pp 219–226 | Cite as

Pancreatic islets subjected to different concentrations of glucose in vitro

A study with special regard to mitochondrial changes
  • Lennart Boquist


Isolated pancreatic islets of mice and gerbils were cultured for 6 days at low (2 mM) or high (20 mM) concentrations of glucose after which they were studied using qualitative and quantitative electron microscopy, histo- and microchemistry, and X-ray microanalysis. Compared with the islets cultured at high glucose, those subjected to low glucose exhibited enhanced succinate dehydrogenase activity, a decreased content of adenosine triphosphate, and an increased volume of B-cell mitochondria which often were rounded or oval.

Key words

Pancreatic B-cells Mitochondria ATP Glucose effect Succinate dehydrogenase 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Lennart Boquist
    • 1
  1. 1.Department of PathologyUniversity of UmeåUmeåSweden

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