Surface configuration of mesothelial cells in effusions
- 30 Downloads
Surface configuration of mesothelial cells identified by light microscopy (LM) has been studied by scanning electron microscopy (SEM). It has been shown that mesothelial cells may have a variable SEM appearance. The surfaces of a small proportion of mesothelial cells are covered by regular microvilli (MV) and show openings of the pinocytotic vesicles. The surfaces of the majority of these cells are covered by vesicles or blebs. An intermediate population of mesothelial cells, i.e., cells displaying side-by-side blebs and MV, has also been observed. The latter cells no longer display pinocytotic vesicles. Occasional mesothelial cells have smooth surfaces. It has been shown by LM and transmission electron microscopy that cells with blebs are viable and capable of mitotic activity. It is concluded that mesothelial cells, detached from their epithelial setting, lose microvilli and pinocytotic vesicles and acquire surface blebs. The possible relationship between mesothelial cells and macrophages based on surface features has been discussed.
Key wordsMesothelial cells Macrophages Cancer cells Microvilli Surface Configuration
Unable to display preview. Download preview PDF.
- 2.Bacalos, D., Constantakis, N., Tsicricas, Th.: Recognition of malignant cells in pleural and peritoneal effusions. Acta Cytol.18, 118–121 (1974)Google Scholar
- 4.Domagala, W., Koss, L.G.: Configuration of surfaces of human cancer cells in effusions. A scanning electron microscopic study of microvilli. Virchows Arch. B Cell Path.26, 27–42 (1977)Google Scholar
- 12.Jangitz, H.: Vergleichende elektronoptische Untersuchungen an Mesotheliomzellen. Arch. Geschwulstforsch.47, 204–209 (1977)Google Scholar
- 14.Koss, L.G.: Diagnostic cytology and its histopathologic bases. 3rd ed. Philadelphia: J.B. Lippincott Co. 1979Google Scholar
- 15.Krivinkova, H., Ponten, J., Blöndal, T.: The diagnosis of cancer from body fluids. A comparison of cytology, DNA measurement, tissue culture, scanning and transmission microscopy. Acta path. Microbiol. Scand. Sect. A84, 455–467 (1976)Google Scholar
- 19.Mohr, W., Beneke, G., Murr, L.: Untersuchungen zur Mitreaktion der Pleura bei peritonealen Reizungen. Path. Microbiol.37, 459–468 (1971)Google Scholar
- 25.Spriggs, A.I.: The cytology of effusions in the pleural, pericardial, and peritoneal cavities. Ed. 2. London: William Heinemann 1972Google Scholar