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Virchows Archiv B

, Volume 30, Issue 1, pp 231–243 | Cite as

Surface configuration of mesothelial cells in effusions

A comparative light microscopic and scanning electron microscopic study
  • Wenancjusz Domagala
  • Leopold G. Koss
Article
  • 31 Downloads

Summary

Surface configuration of mesothelial cells identified by light microscopy (LM) has been studied by scanning electron microscopy (SEM). It has been shown that mesothelial cells may have a variable SEM appearance. The surfaces of a small proportion of mesothelial cells are covered by regular microvilli (MV) and show openings of the pinocytotic vesicles. The surfaces of the majority of these cells are covered by vesicles or blebs. An intermediate population of mesothelial cells, i.e., cells displaying side-by-side blebs and MV, has also been observed. The latter cells no longer display pinocytotic vesicles. Occasional mesothelial cells have smooth surfaces. It has been shown by LM and transmission electron microscopy that cells with blebs are viable and capable of mitotic activity. It is concluded that mesothelial cells, detached from their epithelial setting, lose microvilli and pinocytotic vesicles and acquire surface blebs. The possible relationship between mesothelial cells and macrophages based on surface features has been discussed.

Key words

Mesothelial cells Macrophages Cancer cells Microvilli Surface Configuration 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Wenancjusz Domagala
    • 1
    • 2
  • Leopold G. Koss
    • 1
    • 2
  1. 1.Department of Pathology, Montefiore Hospital and Medical CenterAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Electron MicroscopyMedical AcademySzczecinPoland

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