Virchows Archiv B

, 32:147 | Cite as

Sarcoid macrophage giant cells

Ultrastructure and lysozyme content
  • Ian Carr


Examination of the sarcoid granuloma by electron microscopic and electron microscopic immunocytochemical techniques shows that the sarcoid macrophage giant cell is rich in lysozyme, present within the centre of the syncytium in dense granules ∼ 200 nm in diameter. The ultrastructure of the syncytium is that of an actively secretory cell, suggesting that the sarcoid macrophage giant cell actively produces as well as stores lysozyme, rather than being a fusion product of mononuclear cells which produce lysozyme, or being a site of storage of ingested lysozyme.

Key words

Macrophage Lysozyme Sarcoidosis Giant cells Granuloma 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Ian Carr
    • 1
  1. 1.Department of PathologyUniversity of SaskatchewanSaskatoonCanada

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