Summary
The effects of T-2 toxin, Fusarenon X (FX), and Nivalenol (NV) on the bursa of Fabricius in the day-old chick were examined. After injections of 5 mg/kg of the mycotoxins into the residual yolk sac, cellular injury was limited at first to the smaller epithelial cells with coarse microvilli, which were located in the central portion of the follicle-associated epithelium. Subsequently necrosis spread out to the periphery. Degeneration and necrosis followed in the lymphoid cells in the lymphoid follicles. The other epithelial components in the follicle were relatively resistant to the mycotoxins. Both FX and NV were less potent than T-2 toxin, although the effects on the bursa of Fabricius were essentially the same. These findings suggest that the follicle-associated epithelium is clearly distinguished from other epithelial components in the bursa of Fabricius in day-old chicks.
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This work was supported in part by a Grant-in-Aid for Research of Injuries in Haematopoetic Organs by Mycotoxins from Science and Technology Agency
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Terao, K., Kera, K. & Yazima, T. The effects of trichothecene toxins on the bursa of fabricius in day-old chicks. Virchows Arch. B Cell Path. 27, 359–370 (1978). https://doi.org/10.1007/BF02889007
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DOI: https://doi.org/10.1007/BF02889007