Additional pathological features in epileptic patients secondary to brain tumors — A report of 50 cases

  • Shi Ting-hui


Not only is surgery a better therapy for intractable seizures, but it may also open up the possibilities of further revealing the mysteries of epilepsy by pathologic observation. The present study covered 50 cases of drug-resistant seizures due to brain tumors verified ty operation. Apart from the morphological changes directly related to brain tumors, there appeared to be some additional pathologic features, which could be grouped under four heads, i.e., cortical architectural and neuronal abnormalities, large malformations, pathologic changes in or adjacent to the tumor tissue, and other abnormalities. In the present paper the questions as to the pathogenesis of seizures [and the origin of tumors are discussed. The results of our study suggest that the coexistence of neoplastic transformation and histo-architectural abnormalities might be a morphologic feature in cases of brain gliomas associated with seizures.

Key words

intractable seizures primary brain tumor corticectomy lobectomy pathological features 


  1. 1.
    Mathieson G. Pathologic aspects of epilepsy with special reference to the surgical pathology of focal cerebral seizures. Advanc Neurol 1975; 8: 107–37.Google Scholar
  2. 2.
    Penfield W, et al. Epilepsy and the Functional Anatomy of the Human Brain. Boston, Little, Brown; 1954: 342.Google Scholar
  3. 3.
    Blune WT, et al. Childhood brain tumors presenting as chronic uncontrolled focal seizure disorders. Ann Neurol 1982; 12: 538–41.CrossRefGoogle Scholar
  4. 4.
    Odom GL, et al. Brain tumors in children: clinical analysis of 164 cases. Pediatrics 1956; 18: 856–69.PubMedGoogle Scholar
  5. 5.
    Blanc FEL, et al. Cerebral seizures and brain tumors. In: Handbook of Neurology, P. J. Vinken & G. W. Bruyn eds New York, Elseveier. 1974:15: 295–301.Google Scholar
  6. 6.
    Falconer MA, et al. Etiology and pathogenesis of temporal lobe epilepsy. Arch Neurol 1964; 10: 233–48.PubMedGoogle Scholar
  7. 7.
    Penfield W. Temporal lobe epilepsy. Br J Surg 1954; 41: 337–43.PubMedCrossRefGoogle Scholar
  8. 8.
    Mathieson G. Pathology of temporal lobe foci. Advanc Neurol 1975; 11: 163–85.Google Scholar
  9. 9.
    Rubinstein LJ. Tumors of the central nervous system. In: Atlas of Tumor Pathology, H. I. Firminger eds. Washington DC: Armed Forces Institute of Pathology. 2nd series, fascicle 6, 1972: 1.Google Scholar
  10. 10.
    Bruner JM, et al. Pathology of temporal lobectomies in young patients. In: Abstracts of the 59th annual meeting. American As sociation of Neuropathologists. 1983, Chapt 39.Google Scholar
  11. 11.
    Meencke HJ, et al. Neuropath ological findings in primary generalised epilepsy; a study of eight cases. Epilepsia 1984; 25: 8–21.PubMedCrossRefGoogle Scholar
  12. 12.
    Galaburda AM, et al. Cytoarchitectonic abnormalities in developmental dyslexia; a case study. Ann Neurol 1979; 6: 94–100.PubMedCrossRefGoogle Scholar
  13. 13.
    Page LK, et al. Childhood epilepsy with late detection of cerebral glioma. J Neurosurg 1969; 31: 253–261.PubMedGoogle Scholar
  14. 14.
    Norbert R, et al. Familial oligodendroglioma. J Neurosurg 1984: 60: 848CrossRefGoogle Scholar

Copyright information

© Springer 1987

Authors and Affiliations

  • Shi Ting-hui
    • 1
  1. 1.Department of Neurology, Tongji HospitalTongji Medical UniversityWuhan

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