Journal of Tongji Medical University

, Volume 7, Issue 2, pp 111–116 | Cite as

The relationship between T cell subsets and T suppressor cell function in hepatitis B

  • Liu Feng
  • Song Pei-hui
  • Hao Lian-jie


75 patients with various types of hepatitis B were studied by the assay of Gattringer’s spontaneous suppressor T cell (STs) function. 24 of them with chronic hepatitis B infection were simultaneously investigated by enumeration of OKT3+, OKT4+, OKT8+ T cell subsets in peripheral blood with staphylococci-conjugated IgG rosette forming technique. Patients with chronic active hepatitis B (CAHB) had a significantly decreased STs function while all but one asymptomatic HBsAg carriers had normal, or even higher than normal, STs function. OKT4/OKT8 ratio was obviously low both in CAH and in chronic persistent hepatitis B (CPHB). Positive relationship between STs function and the proportion of OKT8+ cells was identified while most patients with CAH showed higher proportion of OKT8+ cells and destroyed STs function simultaneously. It is suggested that OKT8+ cells in CAHB and CPHB are not of the same entity. In other words, in CAHB OKT8+ cells include mostly cytotoxic T cells, while in CPH, mostly T suppressors.

Key words

T cell subsets T suppressor relationship chronic active hepatitis B chronic persistent hepatitis B 


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  1. 1.
    Alexander G.J.M. Contrasting relations between suppressor eell function and suppressor cell number in chronic liver disease. The Lancet 1983;8337(c): 1291–6.CrossRefGoogle Scholar
  2. 2.
    Barnaba V, et al. Suppressor cell func tion in chronic liver disease. The Lancet 1983;6:343.Google Scholar
  3. 3.
    Robaeys G, et al. Suppresor cell function in chronic liver disease. The Lancet 1983;6:342.CrossRefGoogle Scholar
  4. 4.
    Gattringer C, et al. Sjoitaneous and ConA-induced suppressor lymphocytes: a comparative study. Immunobiology 1981;159:293–8.PubMedGoogle Scholar
  5. 5.
    1986:293–5.Google Scholar
  6. 6.
    1981;1:10.Google Scholar
  7. 7.
    Chirari F V, et al. Functional properties of lymphocyte subpopulations in hepatitis B virus infection. J Immunol 1981;126;38–46.8.Google Scholar
  8. 8.
    Paradie IL, et al. A comparison between a modified avidin-biotin-immunoperoxidase system and flow cytometry. J Histochem Cytochem 1984;32(4):358–62.Google Scholar
  9. 9.
    Lemm G, et al. Studies on immunoregulatory mechanisms in acute and chronic hepatitis B. Clin exp Immunol 1983; 52:250–8.PubMedGoogle Scholar
  10. 10.
    Earnaba V, et al. Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B infection. Clin exp Immunol 1983;53:281–7.Google Scholar
  11. 11.
    Thomas HC, et al. Peripheral T-cell subsets in chronic hepatitis B virus infection. Hepatology 1982;2(2):116S-21S.Google Scholar
  12. 12.
    Alexander G.J.M. et al. Contrasting relations between suppressor cell function and number (letter). Gut 1983;23:461.Google Scholar
  13. 13.
    Chu CM, et al. Peripheral T-cell subsets in chronic type B hepatitis. Cell Immunol 1984;86:562–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Barnaba V, et al. T cell subsets in the hyporesponsiveness to hepatitis B surface antigen and antigen-specific suppressor lymphocytes in chronic HBV infection. Clin Immunol Immunopathol 1985;34:284–95.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1987

Authors and Affiliations

  • Liu Feng
    • 1
  • Song Pei-hui
    • 1
  • Hao Lian-jie
    • 1
  1. 1.Department of Infectious Diseases, Tongji HospitalTongji Medical UniversityWuhan

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