Summary
The inhibitory effect of hydroxyapatite ultrofine powder (HAUFP) on tumor and the effect on the immunity function of body were investigated. The levels of IL-2 in the spleen cells and serum TNF levels in the tumor-bearing mice at the 7th day and 14th after peritoneal injection of HAUFP were detected by using the methods of colorimetric analysis of MTT and crystal purple decoration, respectively. The disappearance of the ascites of the mice was observed. The results showed that the levels of IL-2 and TNF in the tumor-bearing mice were higher obviously in the drug-treated group than in the control group (P< 0.01), the ascites growth was inhibited. It was suggested that HAUFP could increase the levels of IL-2 and TNF of the tumor-bearing mice and improve the immune function of body.
Similar content being viewed by others
References
Xia Q H, Hu P L, Chen D Det al. DNA damage effect of hydroxyapatite ultrofine powder on W-256 sarcoma cells and lymphocytes in rats. J Tongji Med Univ, 1999, 19(3):161
HASM W-256, Ca2+ 1999, 21(3):17
1994, 10(1):48
1991, 3(5):1
Mcintosh J, Mule J J, Merina M J. Synergistic antitumor effects of immunotherapy with recombint interleuk-2 and recombint necrosis factor alone or combinant with radiotherapy. Int J Cancer, 1988, 42:129
Author information
Authors and Affiliations
Additional information
The project was supported by a grant from national natural science foundation of China (No. 39770225).
Rights and permissions
About this article
Cite this article
Qinghua, X., Haiyang, N., Daoda, C. et al. The effect of hydroxyapatite ultrofine powder on the immunity function of tumor-bearing mice. Current Medical Science 21, 143–144 (2001). https://doi.org/10.1007/BF02888080
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02888080