Journal of Tongji Medical University

, Volume 12, Issue 4, pp 253–256 | Cite as

Effects of acute ingestion of ethanol on hemodynamics and hypoxic pulmonary vasoconstriction in dogs—Role of leukotrienes

  • Lu Chuan-yi
  • Wang Di-xun
  • Yu Shang-bing


The effects of acute intragastric administration of ethanol on hemodynamics and hypoxic pulmonary vasoconstriction were studied in spontaneously breathing dogs. The dogs were given 0.5 g/kg of 10 % ethanol (v/v) in 5 min. Hemodynamic measurements were obtained before and 30 min after ingestion of ethanol. Mean pulmonary arterial pressure and pulmonary vascular resistance increased markedly after ingestion of ethanol, and hypoxic pulmonary vasoconstriction was augmented significantly by ethanol as well. Diethylcarbamazine citrate (DEC), a lipooxygenase inhibitor, inhibited these effects of ethanol in a dosage of 200 mg/kg. The above findings suggest that ethanol can induce pulmonary vasoconstriction, which may be predominantly mediated by leukotrienes (LTs).

Key words

ethanol hypoxia pulmonary circulation 


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  1. 1.
    Drummond WH, et al. Ethanol induces acute pulmonary vasoconstriction in salt-perfused rat lungs. Exp Lung Res 1989;15(3):447.PubMedCrossRefGoogle Scholar
  2. 2.
    Drummond WH, et al. Cyclooxygenase blockers inhibit ethanol-induced pul-monary vasoconstriction in lambs. J Appl Fhysiol 1989; 66(2):822.Google Scholar
  3. 3.
    Koskinen P, et al. Effects of alcohol on systemic and palmonary hemodyna-mics in normal humans. Clin Cardiol 1986; 9(10):479.PubMedCrossRefGoogle Scholar
  4. 4.
    Drummond WH, et al. Ethanol induc-ed dose-dependent vasoconstriction in unanesthetized lambs. Exp Lung Res 1985; 9(3-4):341.PubMedCrossRefGoogle Scholar
  5. 5.
    Kettunen R, et al. Influence of etha-nol on systemic and pulmonary hemo-dynamics in anesthetized dogs. Acta Physiol Scand 1983; 118(3):209.PubMedGoogle Scholar
  6. 6.
    Cheng CP, et al. Acute effects of mildly intoxicating levels of alcohol on left ventricular function in con-scious dogs. J Clin Invest 1990; 85(6): 1858.PubMedCrossRefGoogle Scholar
  7. 7.
    Ahonen E, et al. Combined effect of low doses of proprarolol and ethanol on cardiac function: a comparative study by radionuclide ventriculography in conscious dogs. Pharmacol Toxicol 1987; 61(1):33.PubMedGoogle Scholar
  8. 8.
    Morvai V, et al. Acute effecis of low doses of alcohol on the cardiovascular system in young men. Acta Med Hung 1988; 45(3-4), 339.PubMedGoogle Scholar
  9. 9.
    Rogers PJ, et al. Epicardial coronary artery constriction with intravenous ethanol. Int. J Cardiol 1989; 22(3):301.PubMedCrossRefGoogle Scholar
  10. 10.
    Hayes SN, et al. Ethanol causes epi-cardial coronary artery vasoconstric-tion in the intact dogs. Circulation 1988:78(1): 165.PubMedGoogle Scholar
  11. 11.
    Rhee HM, et al. Vascular responses to vasoactive agents in dietary alcohol-treated rats. Clin Exp Pharmacol Phy-siol Suppl 1989; 15:129.CrossRefGoogle Scholar
  12. 12.
    Burke Wolin TM, et al. Inhibition of cGMP-associated pulmonary arterial relaxation to H202 and 02 by ethanol. Am J Physiol 1990; 258:H1267.Google Scholar
  13. 13.
    Hanna CJ, et al. Slow-reacting subs-tances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro. Nature 1981; 290:343.PubMedCrossRefGoogle Scholar
  14. 14.
    Morganroth ML, et al. Leukotrienes C4 production during hypoxic pulmonary vasoconstriction in isolated rat lungs. Prostaglandins 1984; 28:867.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 1992

Authors and Affiliations

  • Lu Chuan-yi
    • 1
  • Wang Di-xun
    • 1
  • Yu Shang-bing
    • 1
  1. 1.Department of PathophysiologyTongji Medical UniversityWuhan

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