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Journal of Tongji Medical University

, Volume 20, Issue 2, pp 97–99 | Cite as

Augmentation of recombinant CH50 polypeptide on the function of macrophages of mice during chemotherapy

  • Zhang Guimei
  • Feng Zuohua
  • Li Dong
  • Cao Huiqing
  • Zhang Hui
Article

Summary

The immunosuppressive model of mice was made by intraperitoneal injection of cyclophosphamide. The effect of CH50, a recombinant polypeptide of human fibronectin, on macrophages of mice was observed. The results showed that continuous intraperitoneal injection of CH50 could prevent the reduction of the number of monocytes in periphery blood and abdominal cavity by chemotherapeutic agents, enhance the metabolic activity and cytotoxicity of macrophages and augment the proliferation of splenocytes. The results suggested that CH50 is a product which could be used to improve the efficacy of chemotherapy of tumors.

Key words

fibronectin recombinant polypeptide macrophages tumor chemotherapy 

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Copyright information

© Springer 2000

Authors and Affiliations

  • Zhang Guimei
    • 1
  • Feng Zuohua
    • 1
  • Li Dong
    • 1
  • Cao Huiqing
    • 1
  • Zhang Hui
    • 1
  1. 1.Department of Medical Molecular BiologyTongji Medical UniversityWuhan

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