Clinical and biochemical characteristics of growth hormone-secreting pituitary tumors
- 21 Downloads
To investigate the difference of biochemical characteristics on gsp-positive and gsp-negative growth hormone (GH)-secreting pituitary tumors, 18 GH-secreting pituitary tumors were examined for their clinical characteristics and gsp oncogenes. All patients received the pituitary function combinative stimulating test. It was found that there were no difference in the sex, age, tumor size, course of disease and plasma basal GH levels with gsppositive and gsp-negative patients. The plasma levels of PRL were increased in most patients (11/18), and the plasma levels of TSH in gsp-positive patients were higher than those in gsp-negative patients (P < 0.05). There was no significant difference in the responses to pituitary combinative stimulating test in gsp-positive and gsp-negative patients. It was concluded that there was little difference in the clinical biochemical characteristics of gsp-positive with gsp-negative GH-secreting pituitary tumors.
Key wordsgrowth hormone-secreting pituitary tumor gsp oncogene biochemistry
- 1.gsp 2000, 17(l):18Google Scholar
- 4.Adams E F, Mashiter K. Secretion of growth hormone by normal and tumous human pituitary somatotrophs in cell culture. Endocrinology’ 85, Excerpta Medica, 1986. 75Google Scholar
- 6.Bresson-Bepoldin L, Odessa M F, Dufy-Barbe L. GHRP-6 stimulates calcium increase and growth hormone release in human somatotrophs in vitro. Endocrine J, 1994, 2: 793.Google Scholar