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Journal of Tongji Medical University

, Volume 19, Issue 4, pp 295–299 | Cite as

Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitro andin vivo

  • Tao Kaixiong
  • Chen Daoda
  • Chen Jianying
  • Tian Yuan
  • Wu Zaide
  • Wang Xiansong
  • Yang Xiuping
Article

Summary

The adriamycin magnetic microspheres (ADM-MAMs) were prepared by the heat-stabilized protein methods. Their physico-chemical properties were examined; their cytotoxicities against tumor cellsin vitro were assayed by a modified MTT method, and their effects were observed on the implanted gastric tumor in Wistar rats given ADM-MAMs via alimentary canal at the presence of the external magnetic fields. The results showed that the ADM-MAMs were successfully prepared and had cytotoxic effect on tumor cellsin vitro similar to the free ADM (P>0. 05). The inhibitory effects of ADM-MAMs on the implanted gastric tumorin vivo were significantly increased as compared with the controls (P<0. 01). Our results suggested that ADM-MAMs were a new type of adriamycin (ADM) preparation and its form alteration did not affect its anticancer effects.

Key words

adriamycin magnetic microsphere preparation cytotoxicity implanted gastric tumor magnetic field 

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Copyright information

© Springer 1999

Authors and Affiliations

  • Tao Kaixiong
    • 1
  • Chen Daoda
    • 1
  • Chen Jianying
    • 1
  • Tian Yuan
    • 1
  • Wu Zaide
    • 1
  • Wang Xiansong
    • 1
  • Yang Xiuping
    • 1
  1. 1.Department of General SurgeryXiehe Hospital, Tongji Medical UniversityWuhan

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