Association between HPV16/18 infection and expression of P53 protein in laryngeal papillomas
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To understand the relationship between expression of P53 protein and HPV16/18 infection in laryngeal papillomas, PCR and immunohistochemical techniques were used to examine the paraffin-embedded tissue samples of laryngeal papillomas from 35 subjects. HPV 16/18-DNA was found in 24 cases of laryngeal papillomas (68. 8 %). Overexpression of P53 protein was detected in 19 cases (54. 3 %). Both HPV16/18-DNA and overexpression of P53 protein Were demonstrated in 12 cases of laryngeal papillomas (34. 3 %). Our results suggest that HPV16/18 infection and P53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and P53 mutation in tissues of laryngeal papillomas remains to be clarified.