A clinical study of cytomegalovirus infections during pregnancy
- 24 Downloads
Enzyme-linked Immunosorbent Assay (ELISA) was adopted to detect the human cytomegalovirus (HCMV) specific IgG, IgM in the blood samples of 216 pregnant women and the umbilical cord blood, as well as the HCMV antigen in the urine specimens of 91 newborn infants. Emphasis was put on the occurrence of cytomegalovirus infection during pregnancy and influence on both the mother and the infant. Our experimental results showed that HCMV IgG positive rate in the maternal sera as well as in cord sera was 93.98%; HCMV IgM positive rates were 8.8% in maternal sera and 3.7% in cord sera, respectively. In maternal sera IgG-positive group, 31.6% cord sera showed also HCMV IgG positive results. In 91 urine specimens of newborn infants, HCMV-Ag positive specimens accounted for 10.98% (10 cases). The rates of abortion, congenital malformation, stillbirth, premature fetal death, and intrauterine growth retardation (IUGR) were all apparently higher in the HCMV-IgM positive pregnant group than in the HCMV-IgM negative group. The infants of HCMV-IgM positive mothers also showed lower birth weight, height, biparietal diameter, suboccipitobregmatic diameter, occipitofronatal diameter, occipito-mental diameter than the infants of HCMV-IgM negative mothers. Meanwhile, the growth and development indices of the former showed a tendency to decrease. Placenta histological examination showed thac HCMV-IgM positive group had a higher incidence of pathological changes than HCMV-IgM negative group. Altogether, there were 8 cases of cogenital infections.
Key wordshuman cytomegalovirus eugenics intrauterine infection
Unable to display preview. Download preview PDF.
- 1.Stagno S, et al. Congenital cytomegalovirus infection: the relative in portance of primary and recurrent maternal infeetion. Engl J Med, 1982, 306:945Google Scholar
- 2.Griffiths PD, et al. Aprosective study of primary cytomegalovirus infection in pregnant women. Br J Obstet Gynacol, 1980, 87:308Google Scholar
- 4.Stagno S, et al. Immunogloblin M antibodies detected by enzyme linked immunosorbent assay and radioimmunoassay in the diagnosis of cytomegalovirus infections in pregnant women and newborn infants. J Clin Microbiol, 1985, 2:930Google Scholar
- 6.Peckham CS, et al. Cytomegalovirus infection in pregnancy: Preliminary findings from a prospective study. Lancet, 1983,11:352Google Scholar
- 7.Janet S, et al. Cytomegalovirus infection and disease. J Infect Dis, 1985,151:772Google Scholar
- 8.Griffiths PD, et al. Prospective study of primary cytomegalovirus infection during pregnancy: final report. Br J Obstet Gynecol, 1984, 91:305Google Scholar