Summary
Serum lipoprotein (a) [Lp(a)] concentration was determined in 42 patients with primary nephrotic syndrome (NS) and the relationships between Lp (a) and plasma lipids, apolipoproteins, serum creatinine (Scr), albumin, urinary proteins (Upro) were also analyzed. The results showed that: (1) serum Lp(a) concentrations in the patients with NS were higher than those in healthy controls; (2) the levels of serum Lp(a) were correlated positively with total cholesterol (TO, low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), apolipoprotein B (Apo-B), Upros (Upro). It is concluded that the NS patients had the potential risk of suffering from coronary artery disease, glomerular sclerosis and thrombosis. The remission of NS may partially decrease the serum Lp(a) levels. Further studies are needed to explore the prevention and treatment of dislipedemia in patients with NS.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ordonez J D, Robert H, Ellen Ket al. The risk of coronary artery disease among patients with the nephrotic syndrome. Kidney Int, 1990, 37: 243
Murai A, Miyahara T, Fujimoto Met al. Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction. Athrosclerosis, 1986, 59:199
Appel G B, Blum C B, Chien Set al. The hyperlipidemia of the nephrotic syndrome, relation to plasma albumin concentration, oncotic pressure, and viscosity. N Eng J Med, 1985, 312: 1544
Steinberg D, Parthasarphy S, Carew T Eet al. Beyond cholesterol modification of low density lipoprotein that increase its atherogenity. N Engl JMed, 1989, 320:915
Brown M S, Goldstein J L. Teaching old dogmas new tricks. Nature, 1987, 330:113
Galle J, Heinloth A, Schwedler Set al. Effect of HDL and atherogenity lipoprotein on formation of O2 − and rennin release in juxtaglomerular cells. Kidney Int, 1997, 51:253
Dahlen G H, Guyton J R, Arrar Met al. Association of level of lipoprotein (a), plasma lipids and other lipoproteins with coronary artery disease documented by angiography. Circulation, 1986, 74:758
Utermann G. The mysteries of lipoprotein (a). Science, 1989, 246:904
Knight B L, Perombelon Y F, Soutar A Ket al. Catabolism of Lp (a) in familial hypercholesterolaemic subjects. Atherosclerosis, 1991, 87:227
Wanner C, Rader D, Barten Wet al. Elevated plasma Lp(a) in patients with the nephrotic syndrome. Ann Inter Med, 1993, 119:263
Webb A T, Plant M, Reareley D Aet al. Lipid and Lp(a) concentrations in renal transplant patients. Nephrol Dial Transplant, 1992, 7:636
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Xiao, Y., Huiling, W., Zhonghua, Z. et al. Serum lipoprotein (a) concentration in patients with nephrotic syndrome and its clinical implication. Current Medical Science 18, 236–238 (1998). https://doi.org/10.1007/BF02886481
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02886481