Pharmacokinetic study on lovastatin sustained-release tablet and sustained-release capsule in Begal dogs
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This study pharmacokinetically examined the lovastatin sustained-release tablet and sustained-release capsule in Beagle dogs. An reversed-phase HPLC method was established for the determination of lovastatin in Beagle dog plasma. Pharmacokinetic findings were compared among three preparation (lovastatin sustained-release tablet, Tp; sustained-release capsule, Tj and conventional capsule). Our results showed that the pharmacokinetic parameters in 6 dogs after single-dose oral administration of three perparations were calculated. Tmax, Cmax and MRT revealed significant difference (P<0.05). Relative bioavailability was 111.5±16.9% (Tp) and 110.4%±9.6% (T1). The pharmacokinetic parameters in the 6 dogs after multiple-dose oral administration of three perparations, Tmax, Cmax MRT and DF had significant difference (P<0.05); Cav, Cmin and AUC0–24h displayed no significant difference (P>0.05). It is concluded that the lovastatin sustained-release tablet and sustained-release capsule are able to maintain a sustained-release for 24 h.
Key wordslovastatin sustained-release tablets sustained-release capsules pharmacokinetic single-dose multiple-dose
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