Folia Microbiologica

, Volume 36, Issue 5, pp 447–450 | Cite as

Effect of dimethyl sulfoxide on lysine production by a mutant ofBacillus subtilis with low homoserine dehydrogenase activity

  • H. O. Kalcheva
  • V. O. Shanskaya
  • J. Smutny
  • S. S. Maluta


SomeBacillus subtilis mutants with different levels of homoserine dehydrogenase were described. Strains that do not accumulate methionine have a high homoserine dehydrogenase activity. Low activity was detected in mutants where cell growth was completely inhibited by 0.7 mmol/L methionine. A low concentration of dimethyl sulfoxide had a stimulatory effect on lysine production by the methionine-sensitive mutant ofBacillus subtilis.


Homoserine Aspartate Kinase Coryneform Bacterium Lysine Biosynthesis Lysine Production 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1991

Authors and Affiliations

  • H. O. Kalcheva
    • 1
  • V. O. Shanskaya
    • 1
  • J. Smutny
    • 2
  • S. S. Maluta
    • 1
  1. 1.Institute of Molecular Biology and GeneticsKievUSSR
  2. 2.Institute of Animal PhysiologyKošiceCzechoslovakia

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