Inhibition of the incorporation of14C-precursors inMycobacterium smegmatis by antibiotics and chemotherapeutics
- 18 Downloads
Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of14C-adenine and14C-leucine inM. smegmatis. The first group includes compounds significantly inhibiting the incorporation of14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 μg/mL.
KeywordsAnthraquinone Spiramycin Mycobacterium Smegmatis Antituberculosis Drug Clofazimin
Unable to display preview. Download preview PDF.
- Drobnica L’.: Regulation of biochemical processes by different types of thiol agents. (In Slovak) Collection of lectures.Vth Conference of Organic Chemists in Smolenice. Biologically active compounds p. 14 (1976).Google Scholar
- Majtán V., Drobnica L’.: Effect of some new synthetic substances onMycobacterium smegmatis.Folia Microbiol.21, 231 (1976).Google Scholar
- Majtán V., Drobnicová I.: Modification of growth of typical and atypical mycobacteria by antituberculotica.Folia Microbiol.18, 175 (1973).Google Scholar
- Majtán V., Drobnicová I.: Effect of antituberculotics on biosynthetic processes inMycobacterium smegmatis.Folia Microbiol.20, 80 (1975).Google Scholar
- While J.R., White H.L.: Streptomycinoid antibiotics. Synergism by puramycin.Science140, 772 (1964).Google Scholar
- White R.J., Lancini G.C., Silvestri L.G.: Mechanism of action of rifampin onMycobacterium smegmatis.J. Bacteriol.100, 737 (1971).Google Scholar