Folia Microbiologica

, Volume 27, Issue 1, pp 43–48 | Cite as

Inhibition of the incorporation of14C-precursors inMycobacterium smegmatis by antibiotics and chemotherapeutics

  • V. Majtán
  • L’. Drobnica


Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of14C-adenine and14C-leucine inM. smegmatis. The first group includes compounds significantly inhibiting the incorporation of14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 μg/mL.


Anthraquinone Spiramycin Mycobacterium Smegmatis Antituberculosis Drug Clofazimin 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1982

Authors and Affiliations

  • V. Majtán
    • 1
  • L’. Drobnica
    • 2
  1. 1.Research Institute of Preventive MedicineCentre of Epidemiology and MicrobiologyBratislavaCzechoslovakia
  2. 2.Department of Technical Microbiology and Biochemistry, Faculty of Chemical TechnologySlovak Technical UniversityBratislavaCzechoslovakia

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