Indian Journal of Clinical Biochemistry

, Volume 15, Issue 2, pp 63–67 | Cite as

Effect of felodipine on the serum lipid profile of patients with hypertension

  • Maninder Kaur
  • Kiranjeet Kaur
  • Gurdeep Kaur Bedi
  • Gurpreet Singh Sidhu
  • Roopan Sikand
Lipid Lowering Drugs


Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol, serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive patients in a positive way.

Key words

Felodipine Lipid Profile Hypertension 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kannel, W.B., Dawber T.R. and Friedman, G.D. (1964) Risk factors in coronary heart disease: An evaluation of several serum lipids as predictors of coronary heart disease. The Framingham study. Ann Intern Med. 61, 888–889.PubMedGoogle Scholar
  2. 2.
    MacMohan, S.W. and MacDonald, G.J. (1986) Antihypertensive treatment and plasma lipoprotein levels. Amer. J. Med. 80, 40–47.CrossRefGoogle Scholar
  3. 3.
    Weinberger, M.H. (1986) Anti hypertensive therapy and lipids. Am J Med. 80, 64–70.PubMedCrossRefGoogle Scholar
  4. 4.
    Lardinois, C.K. and Neuman, S.L. (1988) The effect of anti-hypertensive agents on serum lipids and lipoproteins. Arch. Int. Med. 148, 1280–1288.CrossRefGoogle Scholar
  5. 5.
    Guido, S. and Joseph, T. (1992) Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet. Indian J. Exp. Biol. 30, 292–294.PubMedGoogle Scholar
  6. 6.
    Jaiprakash, R., Rani, M.N. and Venkataraman, B.V. (1993) Effect of felodipine on serum lipid profile in short term streptozotocin-diabetes in rats. Indian J. Exp Biol. 31, 283–284.PubMedGoogle Scholar
  7. 7.
    Swain, T.R., Das, M., Kanungo, S., Mukherji, D., Mishra, S.S. and Das, M.C. (1997) A comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits. Indain J. Physiol. Pharmacol. 41(3), 269–274.Google Scholar
  8. 8.
    Shionoiri, H., Takizawa, T. and Ohyama, Y. (1994) Felodipine therapy may not alter the glucose and lipid metabolism in hypertensives. Hypertension 23 (Suppl., 215–219.Google Scholar
  9. 9.
    Saltiel, E., Ellrodt, A.G. and Monk, J.P. (1988) Felodipine—A review of its pharmacokinetic and pharmacodynamic properties, and therapeutic use in hypertension. Drugs. 36, 387–428.PubMedCrossRefGoogle Scholar
  10. 10.
    Varley, H., Gowenlock, A.H. and Bell, M. (1991) Practical Clinical Biochemistry; 5th edn. CBS publishers. p. 625–684.Google Scholar
  11. 11.
    Lasser, N.L., Grandits, G. and Caggiula, A.W. (1984) Effect of antihypertensive therapy on plasma lipids and lipoproteins in Multiple Risk factor intervention trial Amer. J. Med. 76, 52–66.PubMedCrossRefGoogle Scholar
  12. 12.
    Ponti G.B., Carnovali, M. and Banderali, G. (1983) Effects of labetalol on the lipid metabolism in hypertensive patients. Curr. Ther. Res. 33, 466–471.Google Scholar
  13. 13.
    Perola, P., Lehtoo, H. and Lammintausta, R. (1985) Metabolic effects of furosemide and the combination of furosemide and triamterene. Curr. Ther. Res. 37, 545–553.Google Scholar
  14. 14.
    Mission, R., Markel, T. and Cutles, R.E. (1984) Comparison of blood pressure, plasma lipid and cardiac performance response to prazosin V/s propranolol in thiazide treate hypertensive patients. Amer. J. Cardiol. 53, 51A-54A.CrossRefGoogle Scholar
  15. 15.
    Kirkendall, W.M., Hammod, J.J. and Thomas, J.C. (1978) Prazosin and clonidine for moderately severe hypertension. J. Amer. Med. Assoc. 240, 2553–56.CrossRefGoogle Scholar
  16. 16.
    Inouye, I.K., Massie, B.M. and Benowitz, N. (1984) Anti hypertensive therapy with diltiazem and comparison with hydrochlorthiazide. Amer. J. Cardiol. 53, 1588–1596.PubMedCrossRefGoogle Scholar
  17. 17.
    Walldius, G. (1984) Effect of verapamil on serum lipoproteins in patients with Angina Pectoris. Acta Med. Scand. Suppl. 681, 43–48.PubMedGoogle Scholar
  18. 18.
    Eltingh, O.P. and Hajjar, D.P. (1985) Nifedipine increases cholesteryl ester hydrolytic activity in lipid laden arterial smooth muscle cells. J. Clin. Invest. 15, 1554–1558.Google Scholar
  19. 19.
    Lipez, L.M., Thorman, A.D. and Mehta, J.L. (1990) Effects of amlodipine on blood pressure, heart rate, catecholamines, lipids and responses to adrenergic stimulus. Amer. J. Cardiol. 66, 1269–1271.CrossRefGoogle Scholar
  20. 20.
    Klein, W.W. (1984) Treatment of hypertension with calcium channel blockers—European data. Amer. J. Med. 76, 143–146Google Scholar
  21. 21.
    Stein, O., Leitersdors, E. and Stein, Y. (1985) Verapamil enhances receptor mediated endocytosis of LDL by aortic cells in culture. Arteriosclerosis 5, 35–44.PubMedGoogle Scholar
  22. 22.
    Fillipovic, I. and Buddecke, E. (1986) Calcium channel blockers stimulate LDL receptor synthesis in human skin fibroblasts. Biochem. Biophys. Res. Commun. 136, 845–850.CrossRefGoogle Scholar

Copyright information

© Association of Clinical Biochemists of India 2000

Authors and Affiliations

  • Maninder Kaur
    • 1
  • Kiranjeet Kaur
    • 1
  • Gurdeep Kaur Bedi
    • 1
  • Gurpreet Singh Sidhu
    • 1
  • Roopan Sikand
    • 1
  1. 1.Departments of Biochemistry & CardiologyGovernment Medical CollegePatiala

Personalised recommendations