Relationship between LTP and the nuclear protein induced by calcineurin
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Results demonstrate that calcineurin plays a role in long term potentiatibn (LTP) in the hippocampus. A 45 ku enzyme was administered, which exhibits Ca2+ /calmodulin independent activity to rats, and the protein components of nuclear extracts from the cell-free system of rat hippocampus were tested. It is found that the level of a component significantly increased in nuclear extracts following the activation of calcineurin. The concentration of the component in the nucleus is also markedly increased following hippocampal LTP elicited by ginsenosides. These results suggest that the activation of calcineurin induces a preexisting protein component to translocate to the nucleus in the hippocampus. The nuclear translocation of the component may be required for LTP in the hippocampus.
Keywordscalcineurin nuclear protein learning and memory long-term potentiation (LTP)
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