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Relationship between histone acetylation/deacetylation and gene transcription

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Chinese Science Bulletin

Abstract

In eukaryotes, nucleosome is the basic unit of chromatin. Nucleosorne is composed of an octamer of histone proteins (two molecules each of histones H2A, H2B, H3 and H4) and DNA strand wound around the octamer. Some data show that core histone octamer can affect gene transcription bothin vitro andin vivo. Recent results indicate that histone acetylation/deacetylation is a key step to regulate activity of genes. This article summarizes some coactivators, such as GCNSp, P300/CBP and TAFII 250, which are recently found to have histone acetyltransferase activity. The relationship between these coactivators and gene activation is also described. Besides, this article concerns some corepressors which have histone deacetylase activity, such as Rpd3p, HDAC2. These corepressors combine with other protein complex and then repress transcription. Finally, some problems to be solved and the future direction in this active field are discussed.

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Authors and Affiliations

  1. Key Laboratory of Cell Proliferation and Regulation Bidogy, Beijing Normal University, 100875, Beijii, China

    Zhen Lu & Yongchao Wang

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  1. Zhen Lu
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  2. Yongchao Wang
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Lu, Z., Wang, Y. Relationship between histone acetylation/deacetylation and gene transcription. Chin.Sci.Bull. 43, 1057–1063 (1998). https://doi.org/10.1007/BF02883072

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  • DOI: https://doi.org/10.1007/BF02883072

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