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Chinese Science Bulletin

, Volume 42, Issue 11, pp 942–947 | Cite as

A urokinase mutant with high fibrin-selectivity

  • Guihong Peng
  • Zhong Ma
  • Ruirong Yu
  • Yuming Xue
  • Dexu Zhu
Bulletin

Keywords

scu-PA tcu-PA site-directed mutagenesis fibrin selectivity 

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References

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    Wrinkler, M. E., Blaber, M., Bennett, G. L., Purification and characterization of recombinant single-chain urokinase product inEscherichia Coli, Biochemistry, 1986, 25: 4041.CrossRefGoogle Scholar
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    Valery, N., Leonid, M. H., Roger, L.et al., Tissue-type plasminogen activator (tPA) interacts wlth urokinase-type plasminogen (uPA) via tPA’ s Lysinc binding site,J. Biol. Chem., 1995, 270: 8680.CrossRefGoogle Scholar

Copyright information

© Science in China Press 1997

Authors and Affiliations

  • Guihong Peng
    • 1
  • Zhong Ma
    • 1
  • Ruirong Yu
    • 1
  • Yuming Xue
    • 1
  • Dexu Zhu
    • 1
  1. 1.Department of Biochemistry, State Key Laboratory of Pharmaceutic BiotechnologyNanjing UniversityNanjingChina

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