Science in China Series C: Life Sciences

, Volume 40, Issue 4, pp 351–355 | Cite as

Crystal structure determination of alkaline haemorrhagin AaH III from snake venom ofAgkistrodon acutus

  • Weimin Gong
  • Maikun Teng
  • Liwen Niu


The haemorrhagin AaH III isolated from the snake venom ofAgkistrodon acutus is one of the few alkaline ones in snake venoms. Its crystals belong to space group P212121 witha = 9. 573 4 nm,b = 4. 996 7 nm andc = 4.728 8 nm. Its crystal structure was determined by the molecular replacement method according to the model of metalloproteinase Adamalysin II from eastern rattlesnake venom. The AaH III structure has been refined by PROLSQ. The finalR factor was 0.254 and the RMS deviations of bond lengths and angles were 0.001 8 nm and 1.5°. The structure comparison suggested that AaH III has a similar structure to other snake venom zinc-metalloproteinases. They all belong to matrix metalloproteinases super-family.


crystal structure haemorrhagin metalloproteinase snake venom 


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Copyright information

© Science in China Press 1997

Authors and Affiliations

  • Weimin Gong
    • 1
  • Maikun Teng
    • 1
    • 2
  • Liwen Niu
    • 1
    • 2
  1. 1.The Young Scientist Laboratory of Structure Biology, Department of BiologyUniversity of Science and Technology of ChinaHefeiChina
  2. 2.State Key Laboratory of BiomacromoleculesBeijingChina

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