Clinical experience with NPH insulin

  • S. K. Fineberg
Original contribution


  1. 1.

    The characteristics of the five types of insulin available and the commonly accepted modes of combining these insulins are briefly reviewed.

  2. 2.

    The advantages of NPH insulin over various combinations and mixtures of protamine zinc insulin with crystalline insulin are discussed.

  3. 3.

    Emphasis is laid upon the fact that NPH insulin is somewhat less intense in action than 2:1 mixtures of regular and protamine zinc insulins and therefore larger doses are often needed. Lack of awareness of this by many physicians has led to inadequate doses of NPH insulin and fallaciously poor results.

  4. 4.

    A guide for the combination of NPH and reg-ular insulin in diabetics requiring more than 100 units of insulin is suggested.



Protamine Regular Insulin Separate Injection Protamine Zinc Insulin Protamine Insulin 
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  1. 1.
    Gabriole, A. J. and Marble, A.: Clinical experience with a new modified protamine insulin (NPH 50), Am. J. Digest. Diseases 16:197–206, 1949Google Scholar
  2. 2.
    Baganz, H. M., Carfagno, S. C, Cowan, B. Y. and Dillon, E. S.: NPH insulin: Its comparison with previous insulin regimens. Am. J. Med. Sci. 222:1–6, 1951PubMedCrossRefGoogle Scholar
  3. 3.
    Stephana, J. W., Donaldson, E. M. and Marble, A.: Use of mixtures of NPH and unmodified insulins, Arch. Int. Med. 88:356, 1951Google Scholar
  4. 4.
    Groff, A. E., Engelhardt, H. T. and Skelton, J. M.: Clinical evaluation of NPH-50 insulin in the management of diabetes mellitus, Texas State Med. J. 47:547, 1951Google Scholar
  5. 5.
    Izzo, J. L.: Studies on modified insulins: I. Comparison of time action curves in stabilized patients with constant hyperglycemia and glycosuria. Proc. Am. Diab. A. 9:227–243, 1949Google Scholar

Copyright information

© Sandfield Publishing Company 1954

Authors and Affiliations

  • S. K. Fineberg
    • 1
  1. 1.Associate Visiting Physician and Physician-in-Charge Diabetic ClinicHarlem HospitalNew York City

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