Folia Microbiologica

, Volume 10, Issue 3, pp 156–162 | Cite as

The pyrogenic effect of scarlet fever toxin

I. Neutralization with antitoxin; the nature of tolerance
  • V. Schuh


The scarlet fever toxin is pyrogenically active. The pyretic reaction can be inhibited with antiserum bothin vitro andin vivo. From the quantitative aspect the pyrogenicity neutralization point corresponds approximately to the equivalence point of the flocculation reaction. The transmission of tolerance with the serum of tolerant animals failed. Tolerance was of short duration; interruption of the series of toxin injections for two days resulted in complete restoration of the animal's sensitivity.

It is argued on the basis of these results that although tolerance carries signs of immunological specificity it cannot be explained in terms of circulating antibodies.


Scarlet Fever Endotoxin Tolerance Endogenous Pyrogen Tolerant Animal Scarlet Fever Toxin 
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Пирогенное действие скарлатинозного токсина. Нейтрализация антитоксином и характер толерантности


Скарлатинозный токсин обладает пирогенным деиствием. Лихорадочную реакцию можно подавить in vitro и in vivo с помщью антисыворотки. Количественно точка нейтрализации пирогенного действия приблизительно отвечает эквивалентной точке реакции флоккуляции. Передача толерантности с сывороткой толерантных животных не удавалссь. Толерантность является кратковременной: после двухдневного перерыва в серии инъекций чувствительность животного возобновляется в полной мере.—На основании полученных результатов делается заключение, что, хотя толерантность носит признаки иммунологической специфичности, она не может быть объяснена циркулирующими антителами.


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Copyright information

© Nakladatelství Československé akademie věd 1965

Authors and Affiliations

  • V. Schuh
    • 1
  1. 1.Institute of Epidemiology and MicrobiologyPrague

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