Crystal structure of hirudonine sulphate—a rare polyamine
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Hirudonine sulphate (C9H23N7. 1·5 H2SO4. 2·5 H2O) is triclinic inPI space group with cell constantsa=7·168(9),b=14·534(6),c=11·918(5) Å, α=110·50(3), β=108·75(6) and γ=79·16(6)°,V=1097(2)Å3,Mr=421·4,Z=2,d x=1·358(2) gcm−3,d c=1·276 gcm−3. MoKα (λ=0·7903 Å), μ=1·94 cm−1,F(000)=436,T=295 K,R(F)=0·144. The structure was solved by direct methods and refined to a final R factor of 0·144 for 1036 unique reflections. One of the sulphur atoms is in special position and is disordered. The amine molecule is hydrogen-bonded to the sulphate oxygen through water molecules. Water channels are formed at unique places involving water oxygens, amine and sulphate oxygens along thea axis.
KeywordsPolyamines hirudonine sulphate water channels
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- Cohen S S 1971Introduction to polyamines (Englewood Cliffs, NJ: Prentice-Hall)Google Scholar
- Fruton J S and Simmonds S 1965General Biochemistry (New Delhi: Asia Publishing House)Google Scholar
- Johnson C K 1965ORTEP: A FORTRAN thermal-ellipsoid plot program for crystal structure illustrations Report ORNL-3794, Oakridge National Laboratory, TennesseeGoogle Scholar
- Main P, Fiske S J, Hull S E, Lessinger L, Germain G, Declercq J P and Woolfson M M 1980A system of computer programs for the automatic solution of crystal structures from X-ray diffraction data University of York, EnglandGoogle Scholar
- Scalabrino G and Ferioli M E 1981Adv. Cancer Res. 35 151Google Scholar
- Scalabrino G and Ferioli M E 1982Adv. Cancer Res. 36 1Google Scholar
- Sheldrick G M 1976SHELX76: Program for crystal structure determination University of Cambridge, EnglandGoogle Scholar
- Stevens L 1967Biochem. J. 103 811Google Scholar
- Vasantha Pattabhi and Chandrasekar K 1982 inConformation in biology (eds) R Srinivasan and R H Sarma (Adenine Press) p. 291Google Scholar