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Folia Microbiologica

, Volume 20, Issue 4, pp 354–364 | Cite as

Cyclic kinetics and mathematical expression of the primary immune response to soluble antigen

VI. The possibility of prediction of plasma cell reaction in the spleen of mice immunized with soluble antigen
  • M. I. Levi
  • N. N. Sakayan
  • M. M. Livshits
  • I. S. Meschcheryakova
Article

Abstract

A mathematical expression of the accumulation of the plasma cells in the spleen of CBA mice immunized intraperitoneally is presented. The dependence of the plasma cell reaction in the spleen on the kinetics of antigen concentration in the blood was confirmed. For the transition from antigen to plasma cells, index A was proposed. The mean values of index A were used for comparison of the calculated and experimental values of the plasma cell reaction and the recorded differences were not great. In a similar way, index A was used for prediction of plasma cell accumulation in the spleen of animals, immunized with a mixture of two soluble antigens — capsular antigen ofPasteurella pestis and complete antigen ofFrancisella tularensis. The calculated values of plasma cell reaction corresponded to experimental values.

Keywords

Plasma Cell Lymphoid Organ Soluble Antigen Tularemia Primary Immune Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1975

Authors and Affiliations

  • M. I. Levi
    • 1
  • N. N. Sakayan
    • 1
  • M. M. Livshits
    • 1
  • I. S. Meschcheryakova
    • 1
  1. 1.Central Control Research Laboratory of the Municipal Disinfection StationMoscowUSSR

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