Science in China Series B: Chemistry

, Volume 41, Issue 4, pp 353–360 | Cite as

Design, synthesis and bioactivity of novel ALS inhibitors (V)

Initial model of the herbicidal sulfonylureas and fused heterocyclic sulfonamides binding with receptor
  • Guangfu Yang
  • Guofeng Zhao
  • Rongjian Lu
  • Huayin Liu
  • Huazheng Yang
Article

Abstract

By means of the X-ray diffraction method, quantum pharmacology analysis and quantitative structure-activity relationships (QSAR) analysis, the structure-activity relationships of the herbicidal sulfonylureas and fused heterocyclic sulfonamides were systematically studied. The results showed that the structure-activity relationships of these two kinds of herbicides were identical and that the heterocyclic ring and sulfonyl moiety in the molecules were their pharmacophores which likely bind in the same receptor sites of acetolactate synthase (ALS). According to these results, the initial model of these two kinds of herbicides binding with the receptor was put forward.

Keywords

sulfonylurea fused heterocyclic sulfonamide X-ray diffraction quantum pharmacology QGAR ALS 

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Copyright information

© Science in China Press 1998

Authors and Affiliations

  • Guangfu Yang
    • 1
  • Guofeng Zhao
    • 1
  • Rongjian Lu
    • 1
  • Huayin Liu
    • 1
  • Huazheng Yang
    • 1
  1. 1.Institute of Elemento-Organic Chemistry, State Key Laboratary of Elemento-Organic ChemistryNankai UniversityTianjinChina

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