Skip to main content
Log in

Effect of boseimycin on some enzyme systems ofBacillus subtilis

  • Published:
Folia Microbiologica Aims and scope Submit manuscript

Abstract

The effect of boseimycin on thein vitro activity andin vivo synthesis of alkaline phosphatase, aconitase and lactate, isocitrate, glutamate and alanine dehydrogenases was studied inBacillus subtilis. At a subinhibitory concentration, synthesis of glutamate dehydrogenase was stimulated but alkaline phosphatase, lactate dehydrogenase and aconitase synthesis was inhibited. On the contrary, boseimycin inhibited slightly the activity of lactate dehydrogenase in cell-free extracts. Glutamate dehydrogenase and aconitase activities were not affected.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Anfinsen C. B.: Aconitase from pig heart muscle.Methods in Enzymol. Acad. Press Inc., N.Y. 1, 695 (1955).

    CAS  Google Scholar 

  • Coleman G., Elliot W. H.: Stimulation of extracellular ribonuclease formation inBacillus subtilis by actinomycin D.Nature 202, 1083 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Coleman G., Elliot W. H.: Extracellular ribonuclease formation inBacillus subtilis and its stimulation by actinomycin D.Biochem. J. 95, 699 (1965).

    PubMed  CAS  Google Scholar 

  • Kadowaki K., Yamaguchi K., Mauro B.: Effect of actinomycin D on protein, ribonucleic acid and enzyme formation inBacillus subtilis.J. Gen. Appl. Microbiol. 12, 157 (1966).

    Article  CAS  Google Scholar 

  • Korstberg A.: Lactic dehydrogenase of muscle.Methods in Enzymol. Acad. Pres. Inc. N.Y. 1, 441 (1955).

    Google Scholar 

  • Lowry O. H., Rosebrough N. J., Farra L., Randal R. J.: Protein measurement with Folin phenol reagent.J. Biol. Chem. 193, 265 (1951).

    PubMed  CAS  Google Scholar 

  • Majumdar S. K., Bose S. K.: Mycobacillin, a new antifungal antibiotic produced byBacillus subtilis.Nature 181, 134 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Mandal A., Majumdar S. K.: Effect of streptomycin on some enzyme systems ofBacillus subtilis.Appl. Microbiol. 16, 1786 (1968).

    PubMed  CAS  Google Scholar 

  • Mishra T. K.: Comparative studies on the effects of boseimycin and streptomycin inBacillus subtilis.Gurr. Sci. 40, 440 (1971).

    Google Scholar 

  • Mishra T. K., Mandi P.: Effects of boseimycin on different cellular processes inBacillus subtilis. Symp. “Control Mechanisms in Cellular Processes” B.A.R.C., Govt. of India, Bombay, pp. 615, 1973.

    Google Scholar 

  • Mishra T. K., Sinha R. K.: Mechanism of action of boseimycin.Experientia 27, 642 (1971).

    Article  Google Scholar 

  • Ochoa S.: Isocitric dehydrogenase system (TPN) from pig heart.Methods in Enzymol. Acad. Press Inc., N.Y. 1, 699 (1955).

    CAS  Google Scholar 

  • Pollock M. R.: Penicillinase synthesis. The differential effect of actinomycin D on the biosynthesis of enzymes inBacillus subtilis andBacillus cereus.Biochem. Biophys. Acta 76, 80 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Sinha R. K.: Boseimycin - A new streptothricin-like antibiotic.J. Antibiot. 23, 360 (1970).

    PubMed  CAS  Google Scholar 

  • Sinha R. K., Nandi P. N.: A new antibacterial agent produced byStreptomyces sp. Ac6 569.Experientia 24, 795 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Steecker H. J.: L-Glutamic dehydrogenase from liver.Methods in Enzymol. Acad. Press Inc., N.Y. 2, 220 (1955).

    Google Scholar 

  • Sypherd P. S., Strauss N.: Chloramphenicol-promoted repression of β-galactosidase synthesis inEscherichia coli.Proc. Natl. Acad. Sci., U.S. 49, 400 (1963).

    Article  CAS  Google Scholar 

  • Zimmer C. H., Triebel H., Thrun H.: Interaction of streptothricin and related antibiotics with nucleic acids.Biochem. Biophys. Acta 145, 742 (1967).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mishea, T.K. Effect of boseimycin on some enzyme systems ofBacillus subtilis . Folia Microbiol 20, 124–129 (1975). https://doi.org/10.1007/BF02876768

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02876768

Keywords

Navigation