Folia Microbiologica

, Volume 23, Issue 3, pp 198–201 | Cite as

Effects of cyanein and ramihyphin A on the dimorphism ofParacoccidioides brasiliensis

  • G. San-Blas
  • F. J. Yegres


As a preliminary step in the study of dimorphism mParacoccidioides brasiliensis, the effects of cyanem and ramihyphin A were studied. These antibiotics have been reported to induce morphological changes in fungi The results obtained suggest that ramihyphin A induce swelling of hyphae while partially inhibiting Y → M transformation with the production of an incipient and swollen mycelium. Cyanem did not affect the mycelial morphology as did ramihyphin A However, the Y → M transformation was inhibited and, also, the M → Y transformation was blocked with the production of a few yeast cells which were not released from the mycelium.


Yeast Cell Pyruvate Kinase Citric Acid Cycle Mycelial Form Histoplasma Capsulatum 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1978

Authors and Affiliations

  • G. San-Blas
    • 1
  • F. J. Yegres
    • 1
  1. 1.Centro de Microbiologia y Biologia CelularInstituto Venezolano de Investigaciones Cientificas, (IVIC)CaracasVenezuela

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