Folia Microbiologica

, Volume 23, Issue 5, pp 385–388 | Cite as

Biosynthesis of fatty acids and sterols in relation to the antibiotic formation inOudemansiella mucida

  • F. Nertjd
  • V. Musílek


The production of mucidin by the basidiomyceteOudemansiella mucida was negatively influenced by the application of D-glucitol as the main carbon source, the effect being independent of the growth rate of the mycelium. The rate of fatty acid synthesis was measured by incorporation of 1-14C-acetate. After 8 days of cultivation, the amount of fatty acids was approximately half that synthetized during cultivation on glucose. The specific rate of incorporation reached its maximum after seven days of cultivation. Incorporation of 2-14C-mevalonate into sterols was the same under the two sets of cultivation conditions. Acetate units from the degraded fatty acids are probably also utilized for antibiotic synthesis.


Fatty Acid Synthesis Submerged Culture Main Carbon Source Label Acetate Glucitol 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1978

Authors and Affiliations

  • F. Nertjd
    • 1
  • V. Musílek
    • 1
  1. 1.Department of Experimental Mycology, Institute of MicrobiologyCzechoslovak Academy of SciencesPrague 4

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