Evaluation of FSH, LH and testosterone levels in different subgroups of infertile males
Gonadotropins (FSH, LH) and testosterone are the prime regulators of germ cell development. Abnormal spermatogenesis is often associated with altered serum gonadotropins and testosterone. FSH, LH and testosterone levels were estimated in 96 infertile men of whom 35 were azoospermic, 35 were oligozoospermic, 11 were with varicocele and 15 were with histopathological abnormalities like hypospermatogenesis, spermatid arrest and sertoli-cell only syndrome. Results showed statistically significant (p<0.05), increase in the mean FSH and LH levels in all the infertile males studied when compared with the fertile controls (n=35). However, there is no significant difference in the mean levels of testosterone between the infertile and fertile men.
Key wordsMale infertility FSH LH Testosterone Varicocele Hypospermatogenesis spermatid arrest Sertoli-cell only syndrome
Unable to display preview. Download preview PDF.
- 1.de Krester, D. M. (1979) Endocrinology of Male Infertility. Brit. Med. Bullet. 35 (2), 187–192.Google Scholar
- 3.Weinbauer, G. F. and Nieschlag, E. (1995) Gonadotropin control of testicular germ cell development. Adv. Exp. Med. Biol. 317, 55–65.Google Scholar
- 6.World Heath Organization (1992) WHO Laboratory manual for the examination of human semen and sperm cervical mucus interaction, 3rd edition, Cambridge: Cambridge University Press.Google Scholar
- 9.Sulthan, C., Craste-de-paulet, B., Audran, F., Iqbal, Y. and Ville, C. (1985) Hormonal evaluation in male infertility. Ann. Biol. Clin. Paris. 43 (1), 63–66.Google Scholar
- 10.Weibauer, G. F. and Nieschlag, E. (1995) Gonadotropin control of testicular germ cell development. Adv. Exp. Med. Biol. 317, 55–65.Google Scholar
- 11.Subhan, F., Tahir, F., Ahmad, R. and Khan, Z. D. (1995) Oligospermia and its relation with hormonal profile. Pak. Med. Assoc. 45 (9), 246–247.Google Scholar
- 14.Smith, S.R., Thompson, S.G., Haines, A.P., Jeffcoate, S.L. and Hendry, W.F. (1985). Plasma concentrations of pituitary and testicular hormones of fertile and infertile men. Clin. Reprod. Fertil. 3 (1), 37–48.Google Scholar
- 22.Weiss, D.B., Gottschalk, S., Zakerman, Z., Baron, E. and Kahaa, Z. (1998) Follicle stimulating hormone in azoospermia in prediction of spermatogenic patterns. Hare fuah, 135 (5−6), 169–175.Google Scholar
- 24.Anderson, R.A., Wallace, E.M., Groome, N.P., Bellis, A.J. and Wu, F.C.W (1997). Physiological relationships between inhibin B, follicle stimulating hormone secretion and spermatogenesis in normal men and response to gonadotrophin suppression by exogenous testosterone. Hum. Reprod. 12, 746–7.PubMedCrossRefGoogle Scholar