Edidence for oxidant injury in patients with postdiarrhoeal acute renal failure
Oxygen free radicals have been implicated in the pathogenesis of ischaemic acute renal failure (ARF). The evidence for this is mainly drawn from studies on experimental models. There are no such studies in postdiarrhoeal ARF, which is common in India and forms an ideal human model of ischaemia-reperfusion injury to the kidney, to confirm the observations made, in experimental models. 12 patients with postdiarrhoeal ARF and 15 healthy volunteers were included in the study. In patients with ARF, plasma lipid peroxides (LPO), superoxide dismutase (SOD), plasma iron and plasma ferritin were significantly increased when compared to controls. Plasma glutathione peroxidase levels were significantly lower in the patients with postdiarrhoeal ARF. All these changes persisted at the end of one week. The results of the study strongly suggest the role of reactive oxygen species in the production of postdiarrhoeal acute renal failure as a result of ischaemia-reperfusion injury that occurs in patients with diarrhoeal illness on fluid replacement therapy. This study helps in providing the markers to monitor antioxidant therapy as a preventive as well as therapeutic measure in cases of postdiarrhoeal acute renal failure.
Key wordsPostdiarrhoeal ARF Lipid peroxides Superoxide dismutase Glutathione peroxidase
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