Serum adenosine deaminase in carcinoma breast

  • Ajay Kumar Khanna
  • Sujit Yadav
  • Z. Ali
  • N. C. Arya
  • Anuradha Khanna
Brief Communications


Serum Adenosine Deaminase (ADA) activity was studied in 20 control cases and 32 patients with carcinoma breast. In control group the ADA activity ranged from 13–94 IU/L with a mean of 43.75±21.55 IU/L while in patients of carcinoma breast it was 16–95 IU/L with a mean of 47.46±22.54 IU/L, but these values were not statistically different. The ADA activity was also compared with other parameters in patients of carcinoma breast but the difference was not statistically significant in the various parameters like duration of disease, menopausal status, tumor size, hemoglobin level, total leucocyte count, absolute lymphocyte count, total serum proteins, serum albumin, histological grade of tumor and lymphocytic infiltration. The only significant difference in ADA activity was when N1 status of lymph node was compared with N2 status of lymph node.

Key words

Serum Adenosine deaminase Carcinoma breast 


  1. 1.
    Sullivan, J.L., Osborne, W.R.A. and Wedgwood (1977) Adenosine deaminase activity in lymphocytes. Br. J. Haematol. 37, 157–158.PubMedGoogle Scholar
  2. 2.
    Piras, M.A., Gakis, C., Budroni, M. and Andreoni, G. (1978) Adenosine deaminase activity in pleural effusion: an aid to differential diagnosis. Br. Med. J. 2, 1751–1752.PubMedCrossRefGoogle Scholar
  3. 3.
    Giblett, E.R., Anderson, J.E., Cohen, F., Pollara, B. and Meuwissen, H.J. (1972) Adenosine deaminase in two patients of severely impaired cellular immunity. Lancet, 2, 1067–1069.PubMedCrossRefGoogle Scholar
  4. 4.
    Tung, R., Silber, R., Qugliata, F., Conclyn, M., Gottesmann, J. and Hirschhorn, R. (1976) ADA activity in CLL. Relationship to B and T cell sub population. J. Clin. Invest. 57, 576–579.CrossRefGoogle Scholar
  5. 5.
    Uberti, J., Johnson, R.M., Talley, R. and Lightbody, J.J. (1976) Decreased lymphocyte adenosine deaminase activity in tumor patients. Cancer Res. 36, 2046–2049.PubMedGoogle Scholar
  6. 6.
    Borzenko, B.G. (1991) Use of the study of DNA metabolism enzyme activities as test system in the treatment of breast cancer. Sov. Med. 2, 14–17.PubMedGoogle Scholar
  7. 7.
    Giusti, G. (1974) In methods in enzymatic analysis, 2nd ed. (H.U. Bergmeyer ed.) 1092–1099, Verlag Chemis, Wienhen.Google Scholar
  8. 8.
    Hirschhom, R., Martiniuk, F. and Rosen, F.S. (1978) Adenosine deaminase activity in normal tissues and tissues from a child with severe combined immunodeficiency and adenosine deaminase deficiency. Clin. Immunol. Immunopathol. 9, 287–292.CrossRefGoogle Scholar
  9. 9.
    Ocana, I., Martirez-Vazquez, J.M., Ribera, E., Segura, R.M. and Pascal, C. (1986) Adenosine deaminase activity in the diagnosis of lymphocytic pelural effusion of tuberculosis, neoplastic and lymphomatous origin. Tubercle 67, 141–145.PubMedCrossRefGoogle Scholar
  10. 10.
    Baganha, M.F., Pego, A., Lima, M.A Gaspar, E.V. and Cardeiro, A.R. (1990) Serum and pleural adenosine deaminase correlation with lymphocytic populations. Chest 93, 605–610.CrossRefGoogle Scholar
  11. 11.
    Inoue, Y., Miura, N., Watanabe, T., Wantanabe, K., Tsutsumi, T., Doutsu, Y., Kohno, S., Kanda, T., Hirota, M. and Hara, K. (1991) The usefulness of pelural biopsy in benign of malignant pleurisy. Nippon Kyobu Shikkan Gakkai Zasshi 29, 332–337.PubMedGoogle Scholar
  12. 12.
    Maeda, K., Morita, K., Shibata, T., Naito, Y. and Mizuno, A. (1992) Simultaneous assay of adenosine deaminase and purine nucleoside phosphorylase activity as possible biochemical means to detect non-Hodgkin lymphomas of the oral cavity. Cancer 70, 20–27.PubMedCrossRefGoogle Scholar
  13. 13.
    Rodriguez, E., Martinez, J.A., Buges, J. and Torres, M. (1993) High adenosine deaminase level in pleural effusion due to bronchoalveolar carcinoma. Chest 103, 978–979.PubMedCrossRefGoogle Scholar

Copyright information

© Association of Clinical Biochemists of India 1996

Authors and Affiliations

  • Ajay Kumar Khanna
    • 1
  • Sujit Yadav
    • 1
  • Z. Ali
    • 2
  • N. C. Arya
    • 3
  • Anuradha Khanna
    • 4
  1. 1.Department of Surgery, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia
  2. 2.Department of Biochemistry, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia
  3. 3.Department of Pathology, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia
  4. 4.Department of Gynecology, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia

Personalised recommendations