Indian Journal of Clinical Biochemistry

, Volume 12, Issue 1, pp 86–90 | Cite as

Modulation of convulsive threshold of pentylene tetrazole by zinc

  • N. Khanna
  • A. Garg
  • K. K. Sharma
  • R. Khosla


In the present study which was aimed to see the effect of zinc on pentylenetetrazole induced convulsive threshold in rats we found that zinc sulfate 100 μg intracerebroventricularly) and pentylenetetrazole (50 mg/kg intraperitoneally) produced dose related seizure activity; however, pretreatment with zinc decreased the threshold, increased the severity, incidence of multiple seizures and total duration of pentylenetetrazole induced seizures. Diazepam (5 mg/kg intraperitoneally) pretreatment increased the threshold and lowered the incidence of convulsions in zinc induced seizures which further confirms that the convulsive effect of zinc is through inhibition of gamma aimino butyric acid.

Key Words

Zinc Pentylentetrazole Diazepam GABA 


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Copyright information

© Association of Clinical Biochemists of India 1997

Authors and Affiliations

  • N. Khanna
    • 1
  • A. Garg
    • 1
  • K. K. Sharma
    • 1
  • R. Khosla
    • 1
  1. 1.Department of PharmacologyUniversity College of Medical Sciences & G.T.B. HospitalDelhi

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