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Indian Journal of Clinical Biochemistry

, Volume 18, Issue 1, pp 71–74 | Cite as

Lipid peroxidation in erythrocytes of patients with type 2 diabetes mellitus

  • P. Ashok Kumar
  • G. Rajagopal
Article

Abstract

Lipid peroxidation by measurement of Thiobarbituric Acid Reactive Substances (TBARS) and antioxidant status by determining the activities of the enzymes, Catalase (Cat), Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) and the level of Reduced Glutathione (GSH) in the erythrocytes of patients with type 2 Diabetes Mellitus were investigated. It was observed that the level of TBARS in the erythrocytes was increased by 50% showing a significant generation of free radicals in the erythrocytes of these patients. The activities of both Cat and SOD were enhanced while that of GPx was not altered. The level of GSH was also not changed.

Key words

Glutathione Type 2 Diabetes Catalase Peroxidase Superoxide Dismutase 

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Copyright information

© Association of Clinical Biochemists of India 2003

Authors and Affiliations

  • P. Ashok Kumar
    • 1
  • G. Rajagopal
    • 1
  1. 1.Department of Biochemistry, Rajah Muthiah Medical CollegeAnnamalai UniversityAnnamalai Nagar

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