Indian Journal of Clinical Biochemistry

, Volume 16, Issue 1, pp 72–76 | Cite as

Enhanced expression of HMG-Y proteins in proliferating tissues



The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group, is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer.

Key Words

HMG-Y proteins Cancer Cell Proliferation 


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Copyright information

© Association of Clinical Biochemists of India 2001

Authors and Affiliations

  1. 1.Department of BiochemistryAll India Institute of Medical SciencesNew DelhiIndia

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