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Indian Journal of Clinical Biochemistry

, Volume 15, Supplement 1, pp 127–135 | Cite as

Host protective immunity and vaccine development studies in lymphatic filariasis

  • M. V. R. Reddy
  • R. Alli
  • B. C. Harinath
Filariasis
  • 62 Downloads

Abstract

Lymphatic filariasis caused mainly by infection fromWuchereria bancrofti andBrugia malayi remains as the major cause of clinical morbidity in tropical and subtropical countries. Development of vaccine against filarial infection can act as additional measure to the existing therapeutic and vector control methods in the control of this disease. The main hurdles in the development of anti-filarial vaccine are the strict primate specificity ofWuchereria bancrofti, the paucity of parasite material, the diversity of clinical manifestations and their associated complex immune responses, lack of clear understanding on host-parasite interactions and the mechanisms involved in protective immunity. However in the past few years, the information generated in immuno-epidemiological studies, correlated with observations in experimental animals suggests that a filarial vaccine is feasible. Initially live irradiated infective larvae have been successfully used to induce high level of protective immunity in several animal models. Applying diverse strategies, variety of purified or recombinant filarial antigens have been explored for their ability to induce protection in different host-parasite systems. Some of these targeted filarial antigens induced high level of resistance in experimental animals against challenge infections. More focussed studies on thorough characterization of parasitological and immunological changes associated with resistance induced by such candidate protective antigens and on delivery mechanisms and safety aspects will be crucial in their selection for possible use in humans.

Key Words

Lymphatic filariasis Wuchereria bancrofti Brugia malayi protective immunity immunoprophylaxis vaccine 

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Copyright information

© Association of Clinical Biochemists of India 2000

Authors and Affiliations

  • M. V. R. Reddy
    • 1
  • R. Alli
    • 1
  • B. C. Harinath
    • 1
  1. 1.Department of Biochemistry & JB Tropical Disease Research CentreMahatma Gandhi Institute of Medical SciencesSevagramIndia

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