Indian Journal of Clinical Biochemistry

, Volume 6, Issue 1, pp 39–45 | Cite as

Effect of L(+)-tartrate on liver enzymes in rats fed with calculi producing diet

  • G. S. Selvam
  • P. Varalakshmi


The influence of L(+)-tartrate on liver cell constituents were investigated, during experimental stone formation in rats. A significant increase in the liver glycollate oxidase activity was observed in the calculogenic group. Tartrate administration had a considerable lowering effect on the liver glycollate oxidase activity and it also lowered the urinary excretion pattern of oxalate. The rats fed with calculi producing diet also exhibited moderately enhanced LDH, (Na+, K+)—and (Ca2+)—ATPase activities. The activities of inorganic pyrophosphatase and aminotransferases were slightly reduced. Acid phosphatase activity was significantly reduced with tartrate treatment. The use of tartrate in urolithiasis as a prophylactic measure to prevent recurrence may be beneficial.


Oxalate Tartrate Calcium Oxalate Urinary Oxalate Inorganic Pyrophosphatase 
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  1. 1.
    Solomons, C.S., Goodman, S.I. andRilay, C.M. (1969) N. Engl. J. Med.276, 207–210.CrossRefGoogle Scholar
  2. 2.
    Coe, E.L. andStrunk, R.C. (1970) Biochim. Biophys. Acta208, 189–202.PubMedGoogle Scholar
  3. 3.
    Liao, L.L. andRichardson, K.E. (1973) Arch. Biochem. Biophys.154, 68–75.PubMedCrossRefGoogle Scholar
  4. 4.
    Fry, D.W. andRichardson, K.E. (1979) Biochim. Biophys. Acta568, 135–144.PubMedGoogle Scholar
  5. 5.
    Selvam, G.S. andVaralakshmi, P. (1989) Medical Science Research17, 685–687.Google Scholar
  6. 6.
    Selvam, G.S. andVaralakshmi, P. (1990) Medical Science Research18, 345–348.Google Scholar
  7. 7.
    Richardson, K.E. (1967) Toxicol. Appl. Pharmacol.10, 40–53.PubMedCrossRefGoogle Scholar
  8. 8.
    Richardson, K.E. (1965) Toxicol. Appl. Pharmacol.7, 507–515.PubMedCrossRefGoogle Scholar
  9. 9.
    Chow, F.H.C., Hamar, D.W. andUdall, R.H. (1975) Invest. Urol.13, 113–116.PubMedGoogle Scholar
  10. 10.
    Hodgkinson, A. andWilliams, A. (1972) Clin. Chim. Acta.36, 127–132.PubMedCrossRefGoogle Scholar
  11. 11.
    Hooper, J. (1956) J. Med. Lab. Tech.13, 470–473.Google Scholar
  12. 12.
    Murthy, M.S.R., Talwar, H.S., Thind, S.K. andNath, R. (1982) Ann. Nutr. Metab.26, 201–208.PubMedGoogle Scholar
  13. 13.
    King, J.C. (1965) In: Practical Clinical enzymology. Ed. D. Van Nostrand Co., London, PP. 83–93.Google Scholar
  14. 14.
    King, J.C. (1965) In: Pratical Clinical enzymology, Ed. D. Van Nostrand Co., London, PP. 121–138.Google Scholar
  15. 15.
    Evans, D.J. Jr. (1969) J. Bacteriol100, 941–942.Google Scholar
  16. 16.
    Bonting, S.L. (1970) In: Membrane and Ion transport. Ed.Bittar, E., Edward, Interscience, London, Vol. 1, PP. 257–363.Google Scholar
  17. 17.
    Hjerten, S. andPan, H. (1983) Biochim. Biophys. Acta755, 457–466.Google Scholar
  18. 18.
    Ohnishi, T., Suzuki, T., Suzuki, Y. andOzawa, K. (1982) Biochim. Biophys., Acta684, 67–74.CrossRefGoogle Scholar
  19. 19.
    Josse, J. (1966) Ann. Rev. Biophys.35, 789–808.Google Scholar
  20. 20.
    King, J.C. (1965) In: Practical clinical enzymology. Ed. D. Van Nostrad Co., London, PP. 191–208.Google Scholar
  21. 21.
    Lowry, O.H., Rosebrough, N.J., Farr, A.I. andRandhall, R.J. (1951) J. Biol. Chem.193, 265–275.PubMedGoogle Scholar
  22. 22.
    De Duve, C. andBaudhuin, P. (1966) Physiol. Rev.46, 323–357.PubMedGoogle Scholar
  23. 23.
    Masters, C.J. andHolmes, R.S. (1977) Physiol. Rev.57, 816–882.PubMedGoogle Scholar
  24. 24.
    Ushijima, Y. (1973) Arch. Biochem. Biophys.155, 361–367.PubMedCrossRefGoogle Scholar
  25. 25.
    Varalakshmi, P. andRichardson, K.E. (1983) Proceedings of the II National Conference, Urolithiasis Society of India. (Ed.) Fazil Marikar Y.M. PP. 135–136.Google Scholar
  26. 26.
    Murthy, M.S.R., Talwar, H.S., Thind, S.K. andNath, R. (1983) Ann. Nutr. Metab.27, 355–360.PubMedGoogle Scholar
  27. 27.
    Richardson, K.E. (1973) Toxicol. Appl. Pharmacol.24, 530–538.PubMedCrossRefGoogle Scholar
  28. 28.
    Varalakshmi, P. andRichardson, K.E. (1983) Biochim. Biophys. Acta757, 1–7.PubMedGoogle Scholar
  29. 29.
    Kielly, W.W. (1961) In: The Enzymes. Boyer P.D., Lardy H. and Myrback (Eds.), 2nd Edition, Academic Press, New York, PP. 149–168.Google Scholar
  30. 30.
    McNamara, D.B., Singh, J.N. andDhalla, N.S. (1974) J. Biochem.76, 603–609.PubMedGoogle Scholar
  31. 31.
    Dhalla, N.S. andLee, S.L. (1976) Br. J. Pharmacol.57, 215–221.PubMedGoogle Scholar
  32. 32.
    Felix, R. andFleish, H. (1975) Biochem. J.147, 103–109.PubMedGoogle Scholar
  33. 33.
    Padmaja, T.C. andVaralakshmi, P. (1989) Medical Science Research (UK)17, 589–590.Google Scholar
  34. 34.
    Igarashi, M. andHollander, V.P. (1968) J. Biol. Chem.243, 6084–6089.PubMedGoogle Scholar
  35. 35.
    Murthy, M.S.R., Talwar, H.S., Thind, S.K. andNath, R. (1981) Biochem. Med.26, 77–84.PubMedCrossRefGoogle Scholar
  36. 36.
    Hautmann, R. andLehmann, A. (1980) Eur. J. Clin. Invest.10, 173–176.PubMedCrossRefGoogle Scholar
  37. 37.
    Jayanthi, S., Subha, C. andVaralakshmi, P. (1990) Medical Science Research18, 345–348.Google Scholar
  38. 38.
    Robertson, W.G. andPeacock, M. (1980) Nephron26, 105–110.PubMedCrossRefGoogle Scholar
  39. 39.
    Richardson, K.E. andTolbert, N.E. (1961) J. Biol. Chem.236, 1280–1283.PubMedGoogle Scholar
  40. 40.
    Selvam, G.S. andVaralakshmi, P. (1990) Arogya—J. Health Sci. XVI, 33–42.Google Scholar

Copyright information

© Association of Clinical Biochemists of India 1991

Authors and Affiliations

  • G. S. Selvam
    • 1
  • P. Varalakshmi
    • 1
  1. 1.Department of Medical Biochemistry Post-Graduate Institute of Basic Medical Sciences TaramaniUniversity of MadrasMadrasIndia

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