Folia Microbiologica

, Volume 12, Issue 5, pp 470–476 | Cite as

Study of systemic fever reaction of the delayed type hypersensitivity

IV. Elaboration of a model of fever reaction to ovalbumin
  • A. Castrová
  • J. Pekárek
  • J. Johanovský


The possibility of elaborating a model of fever reaction to a simple protein antigen, ovalbumin, was investigated. Administration of the antigen in adjuvants into the foot-pads or intravenously proved unsatisfactory and did not sensitize the animal to induction of a fever reaction to a challenging dose of antigen. Sensitization by the simultaneous intravenous administration of ovalbumin together with living BCG vaccine yielded positive results. The fever response to ovalbumin is specific, since rabbits sensitized with BCG vaccine only did not respond to the administration of ovalbumin. The degree of fever reactions to tuberculin and ovalbumin in the individual rabbits was more or less proportional. The given model is reproducible and is useful for experimental studies. Further experiments will be necessary, however, for detailed characterization and for analysis of the mechanism (antibody-mediated or delayed type hypersensitivity).


Intravenous Administration Rectal Temperature Protein Antigen Delay Type Hypersensitivity Febrile Response 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1967

Authors and Affiliations

  • A. Castrová
    • 1
  • J. Pekárek
    • 1
  • J. Johanovský
    • 1
  1. 1.Research Institute of ImmunologyPrague 2

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