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Experimental study on the antibacterial effect of origanum volatile oil on dysentery bacilliin vivo andin vitro

  • Liao Fang
  • Huang Qinghua
  • Yang Zhende
  • Xu Hanlin
  • Gao Qinhua
Article

Summary

To observe the germistatic and germicidal effects of origanum volatile oil (OVI) on the dysentery bacteria, the abdominal cavity of mice was infected withShigella sonne (Sh. sonnei) andShigella flexneri (Sh. flexneri) F2a. After OVI was given to the mice via gastric lavage, the effects of OVI on the infected mice were observed. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) for dysentery bacteria were determinedin vitro. The results showed that origanum volatile oil showed obvious protective effect on mice infected withSh. sonnei andSh. flexneri F2a. and it had germistatic and germicidal effects on dysentry bacteria. We are led to conclude that origanum volatile oil is an effective medicine against the infection of dysentery bacteria.

Key words

origanum volatile oil antibacterial effect dysentery bacilli 

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References

  1. 1.
    The Zimbabwe Bangladesh South Africa (Zimbasa) Dysentery Study Group. Multicenter, randomized, double blind clinical trial of short course versus standard course oral ciprofloxacin for Shigella dysenteriae type 1 dysentery in children. Pediatr Infect Dis J, 2002, 21 (12): 1136CrossRefGoogle Scholar
  2. 2.
    Iwalokun B A, Gbenle G O, Adewole T Aet al. Shigellocidal properties of three Nigerian medicinal plants: Ocimum gratissimum, Terminalia avicennoides, and Momordica balsamina. J Health Popul Nutr, 2001, 19 (4): 331PubMedGoogle Scholar
  3. 3.
    Manohar V, Ingram C, Gray Jet al. Antifungal activities of origanum oil against Candida albicans. Mol Cell biochem, 2001, 228(1–2):111PubMedCrossRefGoogle Scholar
  4. 4.
    Compiling Team of the Pharmacopoeia of Chinese Medicinal Herb. Pharmacopoeia of Chinese Medicinal Herb (Book One) (Chinese). Beijing: Publishing House of Peoples Health. 1976, 34Google Scholar
  5. 5.
    Lin Q H, Liu B, Xu Y Wet al. Antibiotic effect in vitro of volatile oil of origanum vulagare L. on enteritiscausing bacteria (Chinese). Chin J Appl Environ Biol, 1997, 3(1): 76Google Scholar
  6. 6.
    Luo C Y, Luo P Y, Xiao X Xet al. Infection of Intestinal Tracts (Chinese). Shanghai: Publishing House of Tongji University, 1990. 43–51Google Scholar
  7. 7.
    Manohar V, Ingram C, Gray Jet al. Antifungal activities of origanum oil against Candida albicans. Mol Cell Biochem, 2001, 228(1–2):111PubMedCrossRefGoogle Scholar
  8. 8.
    Xa CJ, Yu L H. The distribution of Dysentry Bacilli and Monitoring of Their Drug Resistance (Chinese). J Clin Intern Med, 2002, 19(5):388Google Scholar

Copyright information

© Springer 2004

Authors and Affiliations

  • Liao Fang
    • 1
  • Huang Qinghua
    • 1
  • Yang Zhende
    • 1
  • Xu Hanlin
    • 2
  • Gao Qinhua
    • 2
  1. 1.Department of Microbiology, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of MicrobiologyHubei College of Traditional Chinese MedicineWuhanChina

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