Effect of trace elements on the kinetics of calcium oxalate crystallization—Research on urolithiatic inhibitors

Summary

In order to find effective urolithiasis inhibiting factors, calcium oxalate stones were investigated by spectrum analysis. Of the composite trace elements nine were selected to test their effect on the kinetics of calcium oxalate crystallization in artificial and in urinary stone patient’s urine, and in experimental animals respectively. It was found that Mo and Sr could effectively inhibit calcium oxalate crystallization and decrease the renal total and crystalline calcium. The inhibitive effect of the trace elements, the mechanism of action, the required conditions and the way of their affecting the kinetics of calcium oxalate crystallization are discussed. Their clinical significance and the possibility of practical application are referred to.