Acta Academiae Medicinae Wuhan

, Volume 6, Issue 2, pp 100–103 | Cite as

Effect of trace elements on the kinetics of calcium oxalate crystallization—Research on urolithiatic inhibitors

  • Xiao Chuan-guo
  • Xiong Xu-lin


In order to find effective urolithiasis inhibiting factors, calcium oxalate stones were investigated by spectrum analysis. Of the composite trace elements nine were selected to test their effect on the kinetics of calcium oxalate crystallization in artificial and in urinary stone patient’s urine, and in experimental animals respectively. It was found that Mo and Sr could effectively inhibit calcium oxalate crystallization and decrease the renal total and crystalline calcium. The inhibitive effect of the trace elements, the mechanism of action, the required conditions and the way of their affecting the kinetics of calcium oxalate crystallization are discussed. Their clinical significance and the possibility of practical application are referred to.

Key words

trace elements Mo Sr inhibitors urolithiasis crystallization 


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  1. 1.
    Jordan WR, et al. Kinetics of early time calcium oxalate nephrolithiasis. Invest Urol 1978;15: 465.PubMedGoogle Scholar
  2. 2.
  3. 3.
    Fleish H. Inhibitors and promoters of stone formation. Kidney Int 1978; 13: 361–4.CrossRefGoogle Scholar
  4. 4.
    Schroeder HA, Nason AP. Trace-element analysis in clinical chemistry. Clin Chem 1971;17: 461–74.PubMedGoogle Scholar
  5. 5.
    Nancollas GH. Idiopathic urinary bladder stone disease. DHEW Publication, USA. 1980.Google Scholar

Copyright information

© Wuhan Medical College 1986

Authors and Affiliations

  • Xiao Chuan-guo
    • 1
  • Xiong Xu-lin
    • 1
  1. 1.Section of Urology, Department of Surgery, Xiehe HospitalTongji Medical UniversityWuhan

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