A sensitive and simplified HPLC analysis for the determination of fluconazol in human plasma
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A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging 0–10 μ g/ml was linear with the correlation coefficients of 0.9900. The limit of detection was 0.3 μ g/ml. The average recovery of the drug was 89.1±9.05%. After oral administration of single dose(150mg) of fluconazol in man, Cmax and Tmax were 3 μg/ml and 4hr., respectively.
KeywordsHPLC fluconazol pharmacokinetic studies in man
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