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Archives of Pharmacal Research

, Volume 11, Issue 3, pp 250–252 | Cite as

A sensitive and simplified HPLC analysis for the determination of fluconazol in human plasma

  • Eun J. Kim
  • Hye S. Lee
  • Ok P. Zee
  • Sung T. Lee
Notes

Abstract

A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging 0–10 μ g/ml was linear with the correlation coefficients of 0.9900. The limit of detection was 0.3 μ g/ml. The average recovery of the drug was 89.1±9.05%. After oral administration of single dose(150mg) of fluconazol in man, Cmax and Tmax were 3 μg/ml and 4hr., respectively.

Keywords

HPLC fluconazol pharmacokinetic studies in man 

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Literature Cited

  1. 1.
    Troke, P.F., Andrews, R.J., Brammer, K.W., Marriott, M.S. and Richardson, K.: The activity of UK-49858 in several animal models of infection. 1Xth Int. Cong. Int. Soc. Human Anim. Mycol. abstr. R2-7 (1985).Google Scholar
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    Humphrey, M.J., Jevons, S. and Tarbit, M.H.: Pharmacokinetic Evaluation of UK-49858, a metabolically stable Triazole antifungal drug, In Animals and Humans.Antimicrob. Agents Chemother. 28, 648 (1985).PubMedGoogle Scholar
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    Analysis of Fluconazol in Human Plasma using an automated HPLC method. Pfizer Central Research, Department of drug metabolism, 1986 (Unpublished Information).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1988

Authors and Affiliations

  • Eun J. Kim
    • 1
  • Hye S. Lee
    • 1
  • Ok P. Zee
    • 1
  • Sung T. Lee
    • 2
  1. 1.Korea Research Institute of Chemical Technology (KRICT)Daejon
  2. 2.Department of BiologyKorea Institute of Technology (KIT)DaejonKorea

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