Archives of Pharmacal Research

, Volume 11, Issue 3, pp 197–202 | Cite as

Saponins and flavonoid glycosides from yellow sweetclover

  • Sam Sik Kang
  • Young Soon Lee
  • Eun Bang Lee
Original Articles


A new saponin, 3-O-[a-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl(1→2)-β-D-glucuronopyranosyl]soyasapogenol B carboxylate (6) has been isolated from the medicinal plant yellow sweetclover together with azukisaponin II(7), robinin(8), and clovin(9). 7, 8, and9 are reported for the first time from this plant. The new saponin(6) exhibited inhibitory action on leucocyte migration in inflammation.


Yellow sweetclover Leguminosae saponin azukisaponin V carboxylate azukisaponin II flavonoid glycoside robinin clovin leucocyte migration inhibitor 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Duke, J.A.: Handbook of medicinal herbs, CRC Press, Inc., Florida, p. 305 (1985).Google Scholar
  2. 2.
    Kang, S.S. Lee, Y.S., and Lee, E.B.: Isolation of azukisaponin V possessing leucocyte migration inhibitory activity fromMelilotus officinalis.Kor. J. Pharmacogn. 18, 89 (1987).Google Scholar
  3. 3.
    Kang, S.S., Lim, C.-H., and Lee, S.Y.: Soyasapogenols B and E fromMelilotus officinalis.Arch. Pharm. Res. 19, 9 (1987).CrossRefGoogle Scholar
  4. 4.
    Kang, S.S. and Woo, W.S.: Melilotigenin, a new Sapogenin fromMelilotus officinalis.J. Nat. Prod. 51, 335 (1988).CrossRefGoogle Scholar
  5. 5.
    Kitagawa, I., Wang, H.K., Taniyama, T. and Yoshikawa, M.: Reinvestigation of the structures of soyasapogenols A, B, and E, oleanene-sapogenols from soybean, Structures of Soyasaponins I, II, and III.Chem. Pharm. Bull. 36, 153 (1988).Google Scholar
  6. 6.
    Kitagawa, I., Wang, H.K., Saito, M. and Yoshikawa, M.: Chemical constituents of the seeds ofVigna angularis Ohwi et Ohashi(2), azukisaponins I, II, III, and IV.Chem. Pharm. Bull. 31, 674 (1983).Google Scholar
  7. 7.
    Fukunaga, T., Nishiya, K., Takeya, K., and Itokawa, H.: Studies on the constituents of goat's rue.Chem. Pharm. Bull. 35, 1610 (1987).Google Scholar
  8. 8.
    Kitagawa, I., Wang, H.K., Saito, M., and Yoshikawa, H.: Chemical constituents of the seeds ofVigna angularis Ohwi et Ohashi(3), azukisaponins V and VI.Chem. Pharm. Bull. 31, 683 (1983).Google Scholar
  9. 9.
    Wenkert, E. and Gottlieb, H.E.: Carbon-13 nuclear magnetic spectroscopy of flavonoid and isoflavonoid compounds.Phytochem. 16, 1811 (1977).CrossRefGoogle Scholar
  10. 10.
    Nicollier, G.F. and Thompson, A.C.: Phytotoxic compounds fromMelilotus alba and isolation and identification of two new flavonoids.J. Agric. Food Chem. 30, 760 (1982).CrossRefGoogle Scholar
  11. 11.
    Schaufelberger, D., Gupta, M.P. and Hostettmann, K.: Flavonol and secoiridoid glycosides fromCoutoubea spicata.Phytochem.26, 2377 (1987).CrossRefGoogle Scholar
  12. 12.
    Ishikawa, H., Mori, Y., and Tsurufuji, S.: The characteristic feature of glucocorticoids after local application with reference to leucocyte migration and protein Exudation.Eur. J. Pharmacol. 7, 201 (1969).PubMedCrossRefGoogle Scholar
  13. 13.
    Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J.: Protein measurement with the folin phenol reagent.J. Biol. Chem. 193, 265 (1951).PubMedGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1988

Authors and Affiliations

  • Sam Sik Kang
    • 1
  • Young Soon Lee
    • 1
  • Eun Bang Lee
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea

Personalised recommendations