Firing properties and classification of MVN neurons in rats

  • Wang Xuwu
  • Kong Weijia


In order to know the effects of caloric stimulation on neuronal firing in medial vestibular nuclei (MVN) by middle ear irrigation, the middle ear was irrigated with ice (4°C), hot (44°C), and warm (37°C) water, and the firing rate of MVN neuron was extracellularly recorded. The results showed that the firing rate of MVN neuron was changed by caloric stimulation, and the majority of MVN neurons showed excitation by irrigation with hot water and inhibition by ice water (type A). The neuronal firing was recovered immediately after the cessation of the stimulation. I It was concluded that the neuronal firing rate in MVN was changed by caloric stimulation in middle ear cavity. The response was different in various neurons.

Key words

vestibular nuclei caloric stimulation electrophysiology 


  1. 1.
    Yamanaka T, Amano T, Sasa M. Prednisolone excitation of medial vestibular nucleus neurons in rat. Eur Arch Otorhinolaryngol, 1995, 252:112PubMedCrossRefGoogle Scholar
  2. 2.
    Nakamura J, Sasa M, Takaori S. Ethanol potentiates the effect of GABA on medial vestibular nucleus neurons responding to horizontal rotation. Life Sciences, 1989, 45:971PubMedCrossRefGoogle Scholar
  3. 3.
    Takeshita S, Sasa M, Ishihara K itet al. Cholinergic and glutamatergic transmission in medial vestibular nucleus neurons responding to lateral roll tilt in rats. Brain Res, 1999, 840:99PubMedCrossRefGoogle Scholar
  4. 4.
    Ris L, Godaux E. Neuronal activity in the vestibular nuclei after contralateral or bilateral labyrinthectomy in the alert guinea pig. J Neurophysiol, 1998, 80:2352PubMedGoogle Scholar
  5. 5.
    Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic Press, 1986.Google Scholar
  6. 6.
    Nishiike S, Takada N, Nakamura Set al. Responses of locus coeruleus neurons to caloric stimulation in rats. Acta Otolaryngol (Stockh), 1995, Suppl 520: 105CrossRefGoogle Scholar
  7. 7.
    Reason J T. Motion sickness adaptation: a neural mismatch model. J R Soc Med, 1978, 71:819PubMedGoogle Scholar
  8. 8.
    Murofushi T, Curthoys I S, Gilchrist D P. Response of guinea pig vestibular nucleus neurons to clicks. Exp Brawn Res, 1996, 111:149Google Scholar
  9. 9.
    Serafin M, de Waele C, Khateb Aet al. Medial vestibular nucleus in the guinea-pig. I. Intrinsic membrane properties in brainstem slice. Exp Brain Res, 1991, 84: 417PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2003

Authors and Affiliations

  • Wang Xuwu
    • 1
  • Kong Weijia
    • 1
  1. 1.Department of Otolaryngology, Xiehe Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Personalised recommendations